Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP
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DOI: 10.1038/s41598-018-26974-5
Abstract: To address the drug-resistance of bacterial pathogens without imposing a selective survival pressure, virulence and biofilms are highly attractive targets. Here, we show that terrein, which was isolated from Aspergillus terreus, reduced virulence factors (elastase,… read more here.
Keywords: pseudomonas aeruginosa; quorum sensing; terrein; quorum ... See more keywords
Large-Scale Production of Bioactive Terrein by Aspergillus terreus Strain S020 Isolated from the Saudi Coast of the Red Sea
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DOI: 10.3390/biom9090480
Abstract: The diversity of symbiotic fungi derived from two marine sponges and sediment collected off Obhur, Jeddah (Saudi Arabia), was investigated in the current study. A total of 23 isolates were purified using a culture-dependent approach.… read more here.
Keywords: terreus strain; strain s020; production; terrein ... See more keywords
Protection against Lipopolysaccharide-Induced Endotoxemia by Terrein Is Mediated by Blocking Interleukin-1β and Interleukin-6 Production
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DOI: 10.3390/ph15111429
Abstract: Terrein is a fungal metabolite and has been known to exert anti-melanogenesis, anti-cancer, and anti-bacterial activities. However, its role in endotoxemia has never been investigated until now. In the present study, we examined the effect… read more here.
Keywords: interleukin interleukin; terrein; induced endotoxemia; lps induced ... See more keywords