HBV-TERT Promoter Integration Harnesses Host ELF4 Resulting in TERT Gene Transcription in Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31231
Abstract: Hepatitis B virus (HBV) integrations are common in hepatocellular carcinoma (HCC). In particular, alterations of TERT gene by HBV integrations are frequent; however the molecular mechanism and functional consequence underlying TERT-HBV integration are unclear. We… read more here.
Keywords: transcription; integration; hbv; tert promoter ... See more keywords
Is it a new culprit? “TERT promoter mutation” in an aggressive pediatric pilocytic astrocytoma
Sign Up to like & getrecommendations! Published in 2020 at "Child's Nervous System"
DOI: 10.1007/s00381-020-04803-3
Abstract: Recent advances in the genomic study have revolutionized the discovery of molecular biomarkers in glioma not only to aid in targeted therapy but also to prognosticate character of tumor and outcome of a patient. The… read more here.
Keywords: tert promoter; astrocytoma; pilocytic astrocytoma; promoter mutation ... See more keywords
Diagnostic implications of TERT promoter mutation status in diffuse gliomas in a routine clinical setting
Sign Up to like & getrecommendations! Published in 2017 at "Virchows Archiv"
DOI: 10.1007/s00428-017-2216-x
Abstract: IDH (isocitrate dehydrogenase) gene mutations are present in most diffuse low-grade gliomas and define the clinico-pathological core of the respective morphologically defined entities. Conversely, according to the 2016 WHO classification, the majority of glioblastomas belong… read more here.
Keywords: promoter mutation; tert promoter; diffuse gliomas; idh wildtype ... See more keywords
TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.07.003
Abstract: The transcriptional de-repression of the telomerase reverse transcriptase (TERT) gene and subsequent activation of telomerase is a prerequisite step in malignant transformation and progression. Recently, the gain-of-function mutation of the TERT promoter was identified in… read more here.
Keywords: mutant tert; tert promoter; promoter; cancer ... See more keywords
TERT promoter mutations identify a high-risk group in metastasis-free advanced thyroid carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of cancer"
DOI: 10.1016/j.ejca.2018.12.003
Abstract: BACKGROUND TERT promoter mutations are associated with adverse clinicopathological characteristics in thyroid carcinomas and considered as a major indicator of poor outcomes. Nevertheless, most studies have pooled heterogeneous types of thyroid carcinomas and have been conducted… read more here.
Keywords: promoter mutations; high risk; tert promoter; promoter ... See more keywords
Telomerase reverse transcriptase (TERT) promoter mutations in primary adenocarcinoma of bladder and urothelial carcinoma with glandular differentiation: pathogenesis and diagnostic implications
Sign Up to like & getrecommendations! Published in 2021 at "Modern Pathology"
DOI: 10.1038/s41379-021-00776-z
Abstract: Telomerase reverse transcriptase (TERT) promoter mutations have been implicated in urothelial carcinogenesis and are present in 60–80% of conventional and variants of urothelial carcinomas. We investigated the prevalence of TERT promoter mutations in 46 cases… read more here.
Keywords: promoter mutations; tert promoter; glandular differentiation; urothelial carcinoma ... See more keywords
Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing
Sign Up to like & getrecommendations! Published in 2021 at "Modern Pathology"
DOI: 10.1038/s41379-021-00787-w
Abstract: Breast fibroepithelial lesions are biphasic tumors which comprise the common benign fibroadenomas (FAs) and the rarer phyllodes tumors (PTs). This study analyzed 262 (42%) conventional FAs, 45 (7%) cellular FAs, and 321 (51%) benign PTs… read more here.
Keywords: differences benign; benign; genetic differences; tert promoter ... See more keywords
TERT promoter hotspot mutations and gene amplification in metaplastic breast cancer
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DOI: 10.1038/s41523-021-00250-8
Abstract: Metaplastic breast cancers (MBCs) are characterized by complex genomes, which seem to vary according to their histologic subtype. TERT promoter hotspot mutations and gene amplification are rare in common forms of breast cancer, but present… read more here.
Keywords: hotspot mutations; tert promoter; promoter; promoter hotspot ... See more keywords
TERT distal promoter GC islands are critical for telomerase and together with DNMT3B silencing may serve as a senescence-inducing agent in gliomas
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurogenetics"
DOI: 10.1080/01677063.2022.2106371
Abstract: Abstract Telomerase is reactivated in the majority of cancers. For instance, in gliomas, it is common that the TERT promoter is mutated. Research on telomere promoter GC islands have been focused primarily on proximal TERT… read more here.
Keywords: promoter; telomerase; tert promoter; gliomas ... See more keywords
A case of aggressive pituitary neuroendocrine tumour with extremely rapid progression: possible diagnostic value of TERT promoter methylation.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2022.2151564
Abstract: Most pituitary adenoma/neuroendocrine tumours (PitNET) are histologically benign and grow slowly; however, a subset of these tumours exhibit a more aggressive clinical course characterized by local invasiveness and early recurrence. These high-risk PitNETs often require… read more here.
Keywords: tert promoter; extremely rapid; case; promoter methylation ... See more keywords
TERT Promoter Mutation Analysis to Distinguish Glioma From Gliosis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlaa004
Abstract: Among the most challenging diagnostic issues in surgical neuropathology is the distinction between scant infiltration by diffuse gliomas and reactive gliosis. The best documented ancillary marker to establish a definitive diagnosis of glioma in this… read more here.
Keywords: gliomas; analysis; tert promoter; gliosis ... See more keywords