Ni-Catalyzed Reductive Coupling of Heteroaryl Bromides with Tertiary Alkyl Halides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03598
Abstract: We disclose here a nickel-catalyzed reductive coupling of bromopyridines with tertiary alkyl bromides for the synthesis of alkylated pyridines bearing an all-carbon quaternary center. This strategy features mild conditions, broad substrate scope, and high functional… read more here.
Keywords: coupling heteroaryl; tertiary alkyl; reductive coupling; heteroaryl bromides ... See more keywords
A Unified and Desymmetric Approach to Chiral Tertiary Alkyl Halides.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12404
Abstract: Enantioenriched tertiary alkyl halides are prevalent in bioactive molecules and can serve as versatile synthetic intermediates to construct complex structures. While conventional access to these motifs often hinges on stereoselective carbon-halogen or carbon-carbon bond formation… read more here.
Keywords: approach chiral; desymmetric approach; tertiary alkyl; unified desymmetric ... See more keywords