I2-Catalyzed Aerobic α,β-Dehydrogenation and Deamination of Tertiary Alkylamines: Highly Selective Synthesis of Polysubstituted Pyrimidines via Hidden Acyclic Enamines.
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DOI: 10.1021/acs.orglett.0c02001
Abstract: A novel and efficient entrance to the pyrimidine skeleton has been presented via the α,β-dehydrogenation and deamination of tertiary alkylamines. This I2-catalyzed dehydrogenative multicomponent procedure utilizes simple aldehydes to trap the hidden enamine intermediates and… read more here.
Keywords: dehydrogenation deamination; deamination tertiary; tertiary alkylamines; catalyzed aerobic ... See more keywords
Pd(II)-Catalyzed Enantioselective C(sp3)–H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines
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DOI: 10.1021/jacs.1c11921
Abstract: Strained aminomethyl-cycloalkanes are a recurrent scaffold in medicinal chemistry due to their unique structural features that give rise to a range of biological properties. Here, we report a palladium-catalyzed enantioselective C(sp3)–H arylation of aminomethyl-cyclopropanes and… read more here.
Keywords: cyclopropanes cyclobutanes; enantioselective sp3; tertiary alkylamines; sp3 arylation ... See more keywords
Copper catalyzed N-formylation of α-silyl-substituted tertiary N-alkylamines by air
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DOI: 10.1039/d0gc01242d
Abstract: A site-selective method to prepare N-formyl amines efficiently that relies on the copper(I)-catalyzed oxidation of α-silyl-substituted tertiary N-alkylamines by air at room temperature is described. The oxidative protocol was shown to exhibit excellent functional group… read more here.
Keywords: silyl substituted; copper; air; substituted tertiary ... See more keywords