Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides
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DOI: 10.1055/s-0037-1610384
Abstract: A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a… read more here.
Keywords: amino; tertiary enamides; nucleophilic addition; intramolecular nucleophilic ... See more keywords
Tertiary Enamides: Versatile and Available Substrates in Synthetic Chemistry.
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DOI: 10.2174/1570179415666181107122814
Abstract: BACKGROUND Enamines and their variant enamides as powerful and versatile synthons have attracted great attention in synthetic chemistry. Enamides display unique stability and reduce enaminic reactivity in view of the electron-withdrawing effect of N-acyl group.… read more here.
Keywords: tertiary enamides; chemistry; available substrates; versatile available ... See more keywords