Tertiary lymphoid structures in head and neck squamous cell carcinoma improve prognosis by recruiting CD8+ T cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13403
Abstract: Tertiary lymphoid structures (TLSs) are formed in long-term chronic inflammation, promoting the local recruitment of lymphocytes, antigen presentation, and regulation of immune response, correlated with a better prognosis for cancer patients. Although studies have been… read more here.
Keywords: cell; prognosis; lymphoid structures; cd8 cells ... See more keywords
Harnessing Nanotheranostics‐Based Dendritic Cells Tracking Mature Tertiary Lymphoid Structures to Boost Anti‐Glioma Immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202425894
Abstract: Anti‐glioma immunotherapy is highly challenging, largely due to poor immune infiltration and restricted immune delivery, resulting in poor patient prognosis. Recent studies suggest that mature tertiary lymphoid structures (mTLSs) promote immune cell infiltration into solid… read more here.
Keywords: tertiary lymphoid; anti glioma; lymphoid structures; glioma immunotherapy ... See more keywords
Tertiary Lymphoid Structures are Linked to Enhanced Antitumor Immunity and Better Prognosis in Muscle‐Invasive Bladder Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202410998
Abstract: The prognosis for muscle‐invasive bladder cancer (MIBC) remains poor, and reliable prognostic markers have yet to be identified. Tertiary lymphoid structures (TLS) have been associated with favorable outcomes in certain cancers. However, the relationship between… read more here.
Keywords: tertiary lymphoid; prognosis muscle; lymphoid structures; muscle invasive ... See more keywords
Spatial Transcriptional Dynamics of CD74⁺ B Cells in Tertiary Lymphoid Structures Drive Immune Evolution in Penile Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202509742
Abstract: Penile squamous cell carcinoma (PSCC) is a malignancy characterized by a poor prognosis and lack of reliable biomarkers, presenting considerable therapeutic challenges. Tertiary lymphoid structures (TLSs) are critical modulators of antitumor immunity; however, the immunological… read more here.
Keywords: tertiary lymphoid; penile squamous; cell carcinoma; cell ... See more keywords
T Cell Exhaustion and Dendritic Cell-Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202514332
Abstract: Locally advanced rectal cancer (LARC) presents significant treatment challenges, particularly in microsatellite stable (MSS) patients, who often show limited response to immunotherapy. In these cases, neoadjuvant chemoradiotherapy (neoCRT) followed by surgery remains the recommended approach.… read more here.
Keywords: tertiary lymphoid; neoadjuvant chemoradiotherapy; response; rectal cancer ... See more keywords
Tertiary lymphoid structures in lung adenocarcinoma: characteristics and related factors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4796
Abstract: Tertiary lymphoid structures (TLSs) are found in a variety of malignancies and affect the growth of tumors, but few studies have addressed their role in lung adenocarcinoma (LAC). We aimed to evaluate clinical features associated… read more here.
Keywords: lung adenocarcinoma; lymphoid structures; adenocarcinoma characteristics; characteristics related ... See more keywords
Triple‐negative breast cancer survival prediction using artificial intelligence through integrated analysis of tertiary lymphoid structures and tumor budding
Sign Up to like & getrecommendations! Published in 2024 at "Cancer"
DOI: 10.1002/cncr.35261
Abstract: Triple‐negative breast cancer (TNBC) is a highly heterogeneous and clinically aggressive disease. Accumulating evidence indicates that tertiary lymphoid structures (TLSs) and tumor budding (TB) are significantly correlated with the outcomes of patients who have TNBC,… read more here.
Keywords: tertiary lymphoid; cancer; breast cancer; lymphoid structures ... See more keywords
Single-Cell and Spatial Transcriptomic Analysis Reveals Shared and Cancer-Type-Specific Cellular Interactions and Chemokine Signaling Associated With Tertiary Lymphoid Structures in Colorectal and Gastric Cancers.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular carcinogenesis"
DOI: 10.1002/mc.70058
Abstract: Tertiary lymphoid structures (TLS) demonstrate prognostic significance and associations with immunotherapy response in gastrointestinal malignancies, though their regulatory mechanisms remain incompletely defined. The current understanding of TLS at single-cell resolution is limited. Here, we integrated… read more here.
Keywords: tertiary lymphoid; cancer; cd8 cells; single cell ... See more keywords
Basics of Inducible Lymphoid Organs.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2020_218
Abstract: Tertiary lymphoid organs (TLOs), also known as inducible lymphoid organs, tertiary lymphoid structures, tertiary lymphoid tissues, or ectopic lymphoid organs are accumulations of cells in chronic inflammation that have been observed in most tissues in… read more here.
Keywords: lymphoid organs; inducible lymphoid; microbiology; tertiary lymphoid ... See more keywords
Multiplex Immunofluorescence Histology for Immune Cell Infiltrates in Melanoma-Associated Tertiary Lymphoid Structures.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1205-7_40
Abstract: The presence of tertiary lymphoid structures (TLS) is correlated with prolonged patient survival in a variety of solid cancers, including melanoma. However, few methods have been described that could enable a more comprehensive understanding of… read more here.
Keywords: immune; infiltrates melanoma; multiplex immunofluorescence; lymphoid structures ... See more keywords
A Quantitative Pathology Approach to Analyze the Development of Human Cancer-Associated Tertiary Lymphoid Structures.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8709-2_5
Abstract: Tertiary lymphoid structures (TLS) develop in the human tumor microenvironment and correlate with prolonged survival in most cancer types. We recently demonstrated that TLS development follows sequential maturation stages and culminates in the generation of… read more here.
Keywords: quantitative pathology; pathology; lymphoid structures; cancer ... See more keywords