Tertiary lymphoid structures in head and neck squamous cell carcinoma improve prognosis by recruiting CD8+ T cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13403
Abstract: Tertiary lymphoid structures (TLSs) are formed in long-term chronic inflammation, promoting the local recruitment of lymphocytes, antigen presentation, and regulation of immune response, correlated with a better prognosis for cancer patients. Although studies have been… read more here.
Keywords: cell; prognosis; lymphoid structures; cd8 cells ... See more keywords
Tertiary lymphoid structures in lung adenocarcinoma: characteristics and related factors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4796
Abstract: Tertiary lymphoid structures (TLSs) are found in a variety of malignancies and affect the growth of tumors, but few studies have addressed their role in lung adenocarcinoma (LAC). We aimed to evaluate clinical features associated… read more here.
Keywords: lung adenocarcinoma; lymphoid structures; adenocarcinoma characteristics; characteristics related ... See more keywords
Basics of Inducible Lymphoid Organs.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2020_218
Abstract: Tertiary lymphoid organs (TLOs), also known as inducible lymphoid organs, tertiary lymphoid structures, tertiary lymphoid tissues, or ectopic lymphoid organs are accumulations of cells in chronic inflammation that have been observed in most tissues in… read more here.
Keywords: lymphoid organs; inducible lymphoid; microbiology; tertiary lymphoid ... See more keywords
Multiplex Immunofluorescence Histology for Immune Cell Infiltrates in Melanoma-Associated Tertiary Lymphoid Structures.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1205-7_40
Abstract: The presence of tertiary lymphoid structures (TLS) is correlated with prolonged patient survival in a variety of solid cancers, including melanoma. However, few methods have been described that could enable a more comprehensive understanding of… read more here.
Keywords: immune; infiltrates melanoma; multiplex immunofluorescence; lymphoid structures ... See more keywords
A Quantitative Pathology Approach to Analyze the Development of Human Cancer-Associated Tertiary Lymphoid Structures.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8709-2_5
Abstract: Tertiary lymphoid structures (TLS) develop in the human tumor microenvironment and correlate with prolonged survival in most cancer types. We recently demonstrated that TLS development follows sequential maturation stages and culminates in the generation of… read more here.
Keywords: quantitative pathology; pathology; lymphoid structures; cancer ... See more keywords
Nanovaccines Fostering Tertiary Lymphoid Structure to Attack Mimicry Nasopharyngeal Carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c09619
Abstract: Tertiary lymphoid structures (TLSs) are formed in inflamed tissues, and recent studies demonstrated that the appearance of TLSs in tumor sites is associated with a good prognosis for tumor patients. However, the process of natural… read more here.
Keywords: nasopharyngeal carcinoma; tumor; tertiary lymphoid; mimicry nasopharyngeal ... See more keywords
Lupus nephritis: Novel role for BAFF in tertiary lymphoid neogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2017.40
Abstract: Research published in The Journal of Immunology reveals an unexpected role for B cell activating factor (BAFF, also known as TNF super family member 13B) in the formation of tertiary lymphoid structures (TLSs) in the… read more here.
Keywords: lupus nephritis; baff; tertiary lymphoid; role ... See more keywords
Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Oral Science"
DOI: 10.1038/s41368-020-00092-3
Abstract: Tertiary lymphoid structures (TLS) are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis. However, the prognostic value of TLSs in oral squamous cell carcinoma (OSCC) is largely unknown, and the association… read more here.
Keywords: prognostic value; oral squamous; squamous cell; cell carcinoma ... See more keywords
Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis
Sign Up to like & getrecommendations! Published in 2018 at "Modern Pathology"
DOI: 10.1038/s41379-018-0113-8
Abstract: The level of tumor-infiltrating lymphocytes and presence of tertiary lymphoid structures are significant prognostic and predictive factors in primary breast cancer. However, the understanding about differences in tumor-infiltrating lymphocytes and tertiary lymphoid structures at various… read more here.
Keywords: infiltrating lymphocytes; tumor infiltrating; lymphoid structures; tertiary lymphoid ... See more keywords
Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29701-x
Abstract: Tertiary lymphoid structures (TLS) are lymph node-like immune cell clusters that emerge during chronic inflammation in non-lymphoid organs like the kidney, but their origin remains not well understood. Here we show, using conditional deletion strategies… read more here.
Keywords: formation; lymphoid structures; loss; notch signaling ... See more keywords
Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208160119
Abstract: Significance Here, we demonstrate that chronic stress induces the formation of tertiary lymphoid organs (TLOs) in the colon of a mouse model of Crohn’s disease (CD)-like ileitis. Stress induces increased production of interleukin-23 (IL-23) and… read more here.
Keywords: stress; stress induces; tertiary lymphoid; formation ... See more keywords