Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents.
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DOI: 10.1021/acs.orglett.7b01796
Abstract: A facile synthetic method for unsymmetrical tertiary phosphine oxides is reported. Sequential treatment of phosphonodithioic acid S,S-di(p-tolyl) esters with two Grignard reagents enabled the stepwise introduction of different carbon substituents on the phosphorus atom. The… read more here.
Keywords: unsymmetrical tertiary; grignard reagents; tertiary phosphine; phosphine oxides ... See more keywords