Nickel-Catalyzed Direct Substitution of Allylic Alcohols with Nitriles: A General Tool for the Construction of Acyclic C2-Tertiary or Quaternary Benzyl Nitriles.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00323
Abstract: A nickel-catalyzed direct reaction of allylic alcohols with benzyl nitrile derivatives has been developed. The method provides an efficient route for the synthesis of nitriles bearing an α-tertiary or quaternary carbon center in good to… read more here.
Keywords: direct substitution; nickel catalyzed; allylic alcohols; catalyzed direct ... See more keywords
Enantioselective Synthesis of 1,2-Diamines Containing Tertiary and Quaternary Centers through Rhodium-Catalyzed DYKAT of Racemic Allylic Trichloroacetimidates.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02256
Abstract: The amination of racemic secondary and tertiary allylic trichloroacetimidates possessing β-nitrogen substituents and proximal nitrogen-containing heterocycles, via chiral diene-ligated rhodium-catalyzed dynamic kinetic asymmetric transformations (DYKAT), provides branched allylic 1,2-diamines with high enantioselectivity. The catalytic system… read more here.
Keywords: allylic trichloroacetimidates; rhodium catalyzed; tertiary quaternary; synthesis diamines ... See more keywords
Pd-Catalyzed Allylic Alkylation of gem-Alkyl,Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers
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DOI: 10.1021/acscatal.7b04313
Abstract: (E)-gem-Alkyl,aryl-disubstituted allyl carbonates can react with ketones under Pd catalysis using a commercially available NHC ligand by suppressing the β-H elimination. Ketones with α-tertiary, β-quaternary carbon stereocenters were produced in high yields with high regio-… read more here.
Keywords: aryl disubstituted; tertiary quaternary; disubstituted allyl; quaternary carbon ... See more keywords
Pd-Catalyzed umpolung asymmetric allylic alkylation of hydrazones to vicinal tertiary and quaternary chiral carbon centers.
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DOI: 10.1039/d1cc07074f
Abstract: Diastereo- and enantioselective construction of vicinal tertiary and quaternary carbon centers is a great challenge in synthetic chemistry. Herein, we report a facile and efficient protocol to construct vicinal tertiary and quaternary chiral carbon centers… read more here.
Keywords: quaternary chiral; chiral carbon; carbon centers; vicinal tertiary ... See more keywords
Abstract P292: Characteristics of Asian Americans With Acute Ischemic Stroke Treated at a Tertiary/Quaternary Stroke Center
Sign Up to like & getrecommendations! Published in 2021 at "Stroke"
DOI: 10.1161/str.52.suppl_1.p292
Abstract: Background: Asian Americans comprise a rapidly increasing segment of the population, but little is known of their outcomes after acute ischemic stroke. We compared Asians and whites presenting to a San Francisco Bay Area tertiary/quaternary… read more here.
Keywords: ischemic stroke; acute ischemic; stroke; asian americans ... See more keywords
Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12070871
Abstract: Glutamine amidotransferases, enzymes that transfer nitrogen from Gln to various cellular metabolites, are modular, with the amidotransferase (GATase) domain hydrolyzing Gln, generating ammonia and the acceptor domain catalyzing the addition of nitrogen onto its cognate… read more here.
Keywords: catalysis; structure; domain; quaternary structure ... See more keywords