Synthesis of γ-Butyrolactones with Chiral Quaternary-Tertiary Stereocenters via Catalytic Asymmetric Mukaiyama-Michael Addition.
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DOI: 10.1021/acs.orglett.4c03373
Abstract: A catalytic asymmetric Mukaiyama-Michael reaction of silyl ketene acetals (SKAs) with α- or β-substituted α,β-unsaturated pyrazolamides was realized with N,N'-dioxide/nickel(II) complex catalysts. Bidentate coordination of the substrate to the catalyst and elongation of the ligand… read more here.
Keywords: mukaiyama michael; quaternary tertiary; tertiary stereocenters; asymmetric mukaiyama ... See more keywords