Protein Macrocyclization for Tertiary Structure Stabilization
Sign Up to like & getrecommendations! Published in 2021 at "Chembiochem"
DOI: 10.1002/cbic.202100111
Abstract: Proteins possess unique molecular recognition capabilities and enzymatic activities, features that are usually tied to a particular tertiary structure. To make use of proteins for biotechnological and biomedical purposes, it is often required to enforce… read more here.
Keywords: structure stabilization; protein macrocyclization; macrocyclization tertiary; tertiary structure ... See more keywords
Cooperative RNA Folding under Cellular Conditions Arises From Both Tertiary Structure Stabilization and Secondary Structure Destabilization.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00325
Abstract: RNA folding has been studied extensively in vitro, typically under dilute solution conditions and abiologically high salt concentrations of 1 M Na+ or 10 mM Mg2+. The cellular environment is very different, with 20-40% crowding… read more here.
Keywords: rna; secondary structure; cellular conditions; rna folding ... See more keywords
Identification and Characterization of New RNA Tetraloop Sequence Families.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00535
Abstract: There is an abundance of RNA sequence information available due to the efforts of sequencing projects. However, current techniques implemented to solve the tertiary structures of RNA, such as NMR and X-ray crystallography, are difficult… read more here.
Keywords: rna; tetraloop sequence; tertiary structure; structure ... See more keywords
RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac040
Abstract: Abstract A plethora of modified nucleotides extends the chemical and conformational space for natural occurring RNAs. tRNAs constitute the class of RNAs with the highest modification rate. The extensive modification modulates their overall stability, the… read more here.
Keywords: tertiary structure; conformational dynamics; modifications stabilize; trna ... See more keywords
Divalent ions tune the kinetics of a bacterial GTPase center rRNA folding transition from secondary to tertiary structure.
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.068361.118
Abstract: Folding of an RNA from secondary to tertiary structure often depends on divalent ions for efficient electrostatic charge screening (nonspecific association) or binding (specific association). To measure how different divalent cations modify folding kinetics of… read more here.
Keywords: gtpase center; divalent ions; tertiary structure; divalent ... See more keywords
Prediction of the RNA Tertiary Structure Based on a Random Sampling Strategy and Parallel Mechanism
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.813604
Abstract: Background: Macromolecule structure prediction remains a fundamental challenge of bioinformatics. Over the past several decades, the Rosetta framework has provided solutions to diverse challenges in computational biology. However, it is challenging to model RNA tertiary… read more here.
Keywords: parallel mechanism; tertiary structure; rna tertiary; prediction ... See more keywords
How Do Phenolic Acids Change the Secondary and Tertiary Structure of Gliadin? Studies with an Application of Spectroscopic Techniques
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116053
Abstract: The effect of the chemical structure of selected phenolic acids on the molecular organization of gliadins was investigated with the application of Fourier Transform Infrared (FTIR) technique, steady-state, and time-resolved fluorescence spectroscopy. Hydroxybenzoic (4-hydroxybenzoic, protocatechuic,… read more here.
Keywords: secondary tertiary; structure; phenolic acids; acids change ... See more keywords
Image-based effective feature generation for protein structural class and ligand binding prediction
Sign Up to like & getrecommendations! Published in 2020 at "PeerJ Computer Science"
DOI: 10.7717/peerj-cs.253
Abstract: Proteins are the building blocks of all cells in both human and all living creatures of the world. Most of the work in the living organism is performed by proteins. Proteins are polymers of amino… read more here.
Keywords: structural class; ligand; ligand binding; tertiary structure ... See more keywords