Using a surrogate with heterogeneous utility to test for a treatment effect
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9602
Abstract: The primary benefit of identifying a valid surrogate marker is the ability to use it in a future trial to test for a treatment effect with shorter follow‐up time or less cost. However, previous work… read more here.
Keywords: test treatment; treatment effect; surrogate; test ... See more keywords
Applying GRADE for diagnosis revealed methodological challenges: an illustrative example for guideline developers.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2020.11.021
Abstract: OBJECTIVE To identify challenges in the application of GRADE for diagnosis when assessing the certainty of evidence in the test-treatment strategy (diagnostic accuracy, test burden, management effectiveness, natural course, linked evidence) in an illustrative example… read more here.
Keywords: grade diagnosis; test treatment; evidence; treatment strategy ... See more keywords
A group sequential test for treatment effect based on the Fine-Gray model.
Sign Up to like & getrecommendations! Published in 2018 at "Biometrics"
DOI: 10.1111/biom.12871
Abstract: Competing risks endpoints arise when patients can fail therapy from several causes. Analyzing these outcomes allows one to assess directly the benefit of treatment on a primary cause of failure in a clinical trial setting.… read more here.
Keywords: test treatment; treatment; sequential test; group sequential ... See more keywords
Test-treatment RCTs are susceptible to bias: a review of the methodological quality of randomized trials that evaluate diagnostic tests
Sign Up to like & getrecommendations! Published in 2017 at "BMC Medical Research Methodology"
DOI: 10.1186/s12874-016-0287-z
Abstract: BackgroundThere is a growing recognition for the need to expand our evidence base for the clinical effectiveness of diagnostic tests. Many international bodies are calling for diagnostic randomized controlled trials to provide the most rigorous… read more here.
Keywords: methodological quality; test treatment; treatment; diagnostic tests ... See more keywords