New imidazolone derivatives comprising a benzoate or sulfonamide moiety as anti-inflammatory and antibacterial inhibitors: Design, synthesis, selective COX-2, DHFR and molecular-modeling study.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103438
Abstract: New imidazol-5-one derivatives 12a,b and 12e, f, 14a,b and 16a,b were synthesized and screened for their in vivo anti-inflammatory activity using a standard acute carrageenan-induced rat paw oedema method. All the tested compounds exhibited good… read more here.
Keywords: anti inflammatory; dhfr; tested compounds; imidazolone derivatives ... See more keywords
Novel Short PEG Chain-Substituted Porphyrins: Synthesis, Photochemistry, and In Vitro Photodynamic Activity against Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231710029
Abstract: This work presents the synthesis and characterization of metal-free, zinc (II), and cobalt (II) porphyrins substituted with short PEG chains. The synthesized compounds were characterized by UV-Vis, 1H and 13C NMR spectroscopy, and MALDI-TOF mass… read more here.
Keywords: photodynamic activity; activity; tested compounds; short peg ... See more keywords
Synthesis, Microbiological Activity and In Silico Investigation for Some Synthesized Coumarin Derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Croatica Chemica Acta"
DOI: 10.5562/cca3637
Abstract: Four 4-hydroxycoumarin derivatives were synthesized and the structure was confirmed by NMR spectroscopy and Mass spectrometry. Tested compounds have shown significant antimicrobial activity against Bacillus subtilis subsp. spizizenii, Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis,… read more here.
Keywords: activity silico; tested compounds; antimicrobial activity; synthesis microbiological ... See more keywords