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   Articles with "testicular damage" as a keyword



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Ergothioneine attenuates varicocele‐induced testicular damage by upregulating HSP90AA1 in rats

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recommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.23301

Abstract: This study investigates the therapeutic effect and the underlying mechanisms of ergothioneine (EGT) on the testicular damage caused by varicocele (VC) in vivo, in vitro, and in silico. This preclinical study combines a series of… read more here.

Keywords: egt; pharmacology; testicular damage; vivo vitro ... See more keywords
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Protective and restorative potency of diosmin natural flavonoid compound against tramadol-induced testicular damage and infertility in male rats

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recommendations! Published in 2022 at "Natural Product Research"

DOI: 10.1080/14786419.2022.2090937

Abstract: Abstract Flavonoids are polyphenolic natural compounds with various biological actions and limited toxicity including diosmin (DM) which is considered a safe flavonoid natural type with anti-inflammatory and antioxidant activities. Tramadol (TM) is a centrally long-acting… read more here.

Keywords: protective restorative; testicular damage; tramadol induced; induced testicular ... See more keywords
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Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damage cure and in silico approach

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recommendations! Published in 2022 at "Toxicology Mechanisms and Methods"

DOI: 10.1080/15376516.2022.2046668

Abstract: Abstract Ellagic acid (EA) has protective effect on testicular damage and this natural compound decreases oxidative damage. The present study aims to examine the preventive effect of ellagic acid (EA) against carbon tetrachloride (CCl4)-induced testicular… read more here.

Keywords: damage; testicular damage; factor; ellagic acid ... See more keywords
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Chloroquine attenuates chronic hypoxia‐induced testicular damage via suppressing endoplasmic reticulum stress and apoptosis in experimental rat model

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recommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"

DOI: 10.1111/1440-1681.13669

Abstract: Chronic hypoxia negatively affects male fertility by causing pathological changes in male reproductive system. However, underlying mechanisms of this damage are unknown. Chloroquine (CLQ) is an anti‐inflammatory agent that is widely used in the treatment… read more here.

Keywords: hypoxia induced; damage; testicular damage; induced testicular ... See more keywords
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Vitamin E improves testicular damage in streptozocin‐induced diabetic rats, via increasing vascular endothelial growth factor and poly(ADP‐ribose) polymerase‐1

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recommendations! Published in 2018 at "Andrologia"

DOI: 10.1111/and.12925

Abstract: The precise mechanism by which diabetes impairs spermatogenesis and testicular function is not exactly known. Vascular endothelial growth factor (VEGF) and poly(ADP‐ribose) polymerase‐1 (PARP‐1) are important for germ cell homeostasis and repair of DNA respectively.… read more here.

Keywords: testicular damage; induced diabetic; parp; damage ... See more keywords
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Alpha‐lipoic acid may ameliorate testicular damage by targeting dox‐induced altered antioxidant parameters, mitofusin‐2 and apoptotic gene expression

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recommendations! Published in 2021 at "Andrologia"

DOI: 10.1111/and.13990

Abstract: In the study, the ameliorating effects of alfa lipoic acid (ALA) against doxorubicin‐induced testicular apoptosis, oxidative stress and disrupted mitochondrial fusion were investigated in male rats. Rats were divided into four groups as control, doxorubicin… read more here.

Keywords: dox induced; testicular damage; ala; dox ... See more keywords
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Dose-dependent effects of taurine against testicular damage in a streptozotocin-induced type 1 diabetes mellitus rat model

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recommendations! Published in 2023 at "International Journal of Immunopathology and Pharmacology"

DOI: 10.1177/03946320231172745

Abstract: Objectives Testicular dysfunction has been associated with chronic hyperglycemia in diabetes mellitus patients. We investigated taurine’s possible mechanisms and protective effects against testicular damage using a rat model of streptozotocin-induced diabetes. Methods Wistar rats (N… read more here.

Keywords: rat model; streptozotocin induced; testicular damage; diabetes mellitus ... See more keywords
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Ghrelin modulates testicular damage in a cryptorchid mouse model

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0177995

Abstract: Cryptorchidism or undescended testis (UDT) is a common congenital abnormality associated with increased risk for developing male infertility and testicular cancer. This study elucidated the effects of endogenous ghrelin or growth hormone secretagogue receptor (GHSR)… read more here.

Keywords: testicular damage; mouse model; cryptorchid mouse; ghrelin ... See more keywords
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Prophylactic and Ameliorative Effects of PPAR-γ Agonist Pioglitazone in Improving Oxidative Stress, Germ Cell Apoptosis and Inflammation in Gentamycin-Induced Testicular Damage in Adult Male Albino Rats

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recommendations! Published in 2022 at "Antioxidants"

DOI: 10.3390/antiox11020191

Abstract: Peroxisome proliferator-activated receptor gamma (PPAR-γ) is ubiquitously expressed in testicular tissue and plays a crucial role in regulating various physiological processes. Pioglitazone (PIO) is one of the PPAR-γ agonists, having anti-oxidant and anti-inflammatory effects. Patients… read more here.

Keywords: damage; testicular damage; adult male; induced testicular ... See more keywords
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Zygo-Albuside A: New Saponin from Zygophyllum album L. with Significant Antioxidant, Anti-Inflammatory and Antiapoptotic Effects against Methotrexate-Induced Testicular Damage

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms231810799

Abstract: Chemical investigation of the crude extract of the aerial part of Zygophyllum album L. (Z. album) led to the isolation of a new saponin, Zygo-albuside A (7), together with seven known compounds, one of them… read more here.

Keywords: zygo albuside; new saponin; testicular damage; album ... See more keywords
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Quercetin Ameliorates Testicular Damage in Zucker Diabetic Fatty Rats through Its Antioxidant, Anti-Inflammatory and Anti-Apoptotic Properties

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232416056

Abstract: The aim of this study was to investigate the effects of quercetin (QUE) on the testicular architecture as well as markers of oxidative, inflammatory, and apoptotic profile of male gonads in Zucker diabetic fatty (ZDF)… read more here.

Keywords: diabetic fatty; zucker diabetic; obese zdf; testicular damage ... See more keywords