Protective Effects of Atorvastatin on LPS‐Induced Testicular Damage: Modulation of Spermatogenesis via PPAR‐γ, NF‐κB, and NLRP3 Pathways
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4851
Abstract: Male infertility represents a considerable global health issue, frequently linked to oxidative stress and inflammation‐related dysfunction of the testes. Atorvastatin (ATV), a commonly prescribed statin, has effects that extend beyond merely lowering lipid levels. Recent… read more here.
Keywords: ppar; protective effects; induced testicular; testicular damage ... See more keywords
Ergothioneine attenuates varicocele‐induced testicular damage by upregulating HSP90AA1 in rats
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23301
Abstract: This study investigates the therapeutic effect and the underlying mechanisms of ergothioneine (EGT) on the testicular damage caused by varicocele (VC) in vivo, in vitro, and in silico. This preclinical study combines a series of… read more here.
Keywords: egt; pharmacology; testicular damage; vivo vitro ... See more keywords
Antioxidant Efficiency of Elettaria cardamomum Essential Oil Against Benzo[a]Pyrene-Induced Testicular Damage via Oxidative Stress Suppression and Modulation of Gene Expression in Rats.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental toxicology"
DOI: 10.1002/tox.24574
Abstract: Benzo[a]pyrene (BaP) is an environmental polycyclic aromatic hydrocarbon known to act as an endocrine disruptor. Cardamom (Elettaria cardamomum) is a widely used spice with strong biological and antioxidant properties. The current work aimed to clarify… read more here.
Keywords: elettaria cardamomum; gene expression; benzo pyrene; testicular damage ... See more keywords
Silver Nanoparticles Loaded with Oleuropein Reduce Doxorubicin-Induced Testicular Damage by Regulating Endoplasmic Reticulum Stress, and Apoptosis
Sign Up to like & getrecommendations! Published in 2024 at "Biological Trace Element Research"
DOI: 10.1007/s12011-024-04058-y
Abstract: Doxorubicin (DOX) is the most used chemotherapeutic agent for treating solid tumors. DOX treatment may lead to testicular damage using oxidative stress, resulting in infertility. These adverse effects may be prevented by the activation of… read more here.
Keywords: agnp; dox; stress; induced testicular ... See more keywords
Protective and restorative potency of diosmin natural flavonoid compound against tramadol-induced testicular damage and infertility in male rats
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2090937
Abstract: Abstract Flavonoids are polyphenolic natural compounds with various biological actions and limited toxicity including diosmin (DM) which is considered a safe flavonoid natural type with anti-inflammatory and antioxidant activities. Tramadol (TM) is a centrally long-acting… read more here.
Keywords: protective restorative; testicular damage; tramadol induced; induced testicular ... See more keywords
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damage cure and in silico approach
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2022.2046668
Abstract: Abstract Ellagic acid (EA) has protective effect on testicular damage and this natural compound decreases oxidative damage. The present study aims to examine the preventive effect of ellagic acid (EA) against carbon tetrachloride (CCl4)-induced testicular… read more here.
Keywords: damage; testicular damage; factor; ellagic acid ... See more keywords
Chloroquine attenuates chronic hypoxia‐induced testicular damage via suppressing endoplasmic reticulum stress and apoptosis in experimental rat model
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13669
Abstract: Chronic hypoxia negatively affects male fertility by causing pathological changes in male reproductive system. However, underlying mechanisms of this damage are unknown. Chloroquine (CLQ) is an anti‐inflammatory agent that is widely used in the treatment… read more here.
Keywords: hypoxia induced; damage; testicular damage; induced testicular ... See more keywords
Vitamin E improves testicular damage in streptozocin‐induced diabetic rats, via increasing vascular endothelial growth factor and poly(ADP‐ribose) polymerase‐1
Sign Up to like & getrecommendations! Published in 2018 at "Andrologia"
DOI: 10.1111/and.12925
Abstract: The precise mechanism by which diabetes impairs spermatogenesis and testicular function is not exactly known. Vascular endothelial growth factor (VEGF) and poly(ADP‐ribose) polymerase‐1 (PARP‐1) are important for germ cell homeostasis and repair of DNA respectively.… read more here.
Keywords: testicular damage; induced diabetic; parp; damage ... See more keywords
Alpha‐lipoic acid may ameliorate testicular damage by targeting dox‐induced altered antioxidant parameters, mitofusin‐2 and apoptotic gene expression
Sign Up to like & getrecommendations! Published in 2021 at "Andrologia"
DOI: 10.1111/and.13990
Abstract: In the study, the ameliorating effects of alfa lipoic acid (ALA) against doxorubicin‐induced testicular apoptosis, oxidative stress and disrupted mitochondrial fusion were investigated in male rats. Rats were divided into four groups as control, doxorubicin… read more here.
Keywords: dox induced; testicular damage; ala; dox ... See more keywords
Dose-dependent effects of taurine against testicular damage in a streptozotocin-induced type 1 diabetes mellitus rat model
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/03946320231172745
Abstract: Objectives Testicular dysfunction has been associated with chronic hyperglycemia in diabetes mellitus patients. We investigated taurine’s possible mechanisms and protective effects against testicular damage using a rat model of streptozotocin-induced diabetes. Methods Wistar rats (N… read more here.
Keywords: rat model; streptozotocin induced; testicular damage; diabetes mellitus ... See more keywords
Ghrelin modulates testicular damage in a cryptorchid mouse model
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DOI: 10.1371/journal.pone.0177995
Abstract: Cryptorchidism or undescended testis (UDT) is a common congenital abnormality associated with increased risk for developing male infertility and testicular cancer. This study elucidated the effects of endogenous ghrelin or growth hormone secretagogue receptor (GHSR)… read more here.
Keywords: testicular damage; mouse model; cryptorchid mouse; ghrelin ... See more keywords