Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives
Sign Up to like & getrecommendations! Published in 2025 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12661
Abstract: Type 2 diabetes mellitus (T2D) is a growing metabolic disorder affecting all age groups and is linked to testiculopathy, a key contributor to male infertility. Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic… read more here.
Keywords: testicular dysfunction; role crem; crem; potential role ... See more keywords
Mitigative Effects of l-Arginine and N-Acetyl Cysteine against Cisplatin-Induced Testicular Dysfunction and Toxicity through the Regulation of Antioxidant, Anti-inflammatory, and Antiapoptotic Markers: Role of miR-155 and miR-34c Expression
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c03742
Abstract: Testicular dysfunction is a common adverse effect of cisplatin (CIS) administration as a chemotherapeutic drug. The current study has outlined the role of micro-RNAs (miR-155 and 34c) in CIS-induced testicular dysfunction and evaluated the protective… read more here.
Keywords: cis; induced testicular; mir 155; expression ... See more keywords
Cholecalciferol alleviates testicular dysfunction in experimental hyperthyroidism via antioxidant, anti-inflammatory and antiapoptotic effects
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2025.2503479
Abstract: Abstract Background This study aimed to investigate the possible protective effect of cholecalciferol against testicular dysfunction in L-thyroxine-induced hyperthyroid rat model. Methods Twenty-four adult male rats were divided into three groups: control, hyperthyroid, and hyperthyroid… read more here.
Keywords: cholecalciferol; serum inflammatory; dysfunction; inflammatory markers ... See more keywords
A Protein from Dioscorea polystachya (Chinese Yam) Improves Hydrocortisone-Induced Testicular Dysfunction by Alleviating Leydig Cell Injury via Upregulation of the Nrf2 Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/3575016
Abstract: Leydig cell injury has been described as a primary driver of testicular dysfunction and is affected by oxidative stress. Dioscorea polystachya (Chinese yam) is used to improve testicular dysfunction in clinical and pharmacological research via… read more here.
Keywords: leydig cell; testicular dysfunction; leydig; chinese yam ... See more keywords
Testicular Regeneration by Secretome Injection in Cisplatin-Induced Testicular Dysfunction in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Animal and Veterinary Sciences"
DOI: 10.17582/journal.aavs/2020/8.1.11.17
Abstract: | Testicular dysfunction is a degenerative disease characterized by germ cell death during the process of spermatogenesis. The secretome, or mesenchymal stem cell-conditioned medium, can promote tissue regeneration because it contains biological substances such as… read more here.
Keywords: dysfunction; testicular dysfunction; group; secretome injection ... See more keywords
Diabetic testicular dysfunction and spermatogenesis impairment: mechanisms and therapeutic prospects
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2025.1653975
Abstract: With the global prevalence of diabetes mellitus (DM) steadily increasing, its impact on male reproductive health has become a growing area of concern. Diabetes-induced testicular damage involves alterations in testicular cell function, hormone levels, and… read more here.
Keywords: diabetic testicular; dysfunction; dysfunction spermatogenesis; impairment ... See more keywords
2-Bromopalmitate-Induced Intestinal Flora Changes and Testicular Dysfunction in Mice
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252111415
Abstract: 2-Bromopalmitate (2-BP) is a palmitoylation inhibitor that can prevent the binding of palmitic acid to proteins, thereby exhibiting significant effects in promoting inflammation and regulating the immune system. However, limited research has been conducted regarding… read more here.
Keywords: induced intestinal; intestinal flora; flora changes; testicular dysfunction ... See more keywords
UPLC-QE-Orbitrap-Based Cell Metabolomics and Network Pharmacology to Reveal the Mechanism of N-Benzylhexadecanamide Isolated from Maca (Lepidium meyenii Walp.) against Testicular Dysfunction
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28104064
Abstract: Testicular dysfunction (TDF) is characterized by testosterone deficiency and is caused by oxidative stress injury in Leydig cells. A natural fatty amide named N-benzylhexadecanamide (NBH), derived from cruciferous maca, has been shown to promote testosterone… read more here.
Keywords: testicular dysfunction; pharmacology; cell metabolomics; network pharmacology ... See more keywords
The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model.
Sign Up to like & getrecommendations! Published in 2017 at "General physiology and biophysics"
DOI: 10.4149/gpb_2016048
Abstract: There is an increasing concern over male reproductive toxicity caused by lead exposure. Folic acid (FA) is supposed to be a promising therapeutic strategy against lead toxicity. Therefore, the aim of this experimental study was… read more here.
Keywords: folic acid; lead; testicular dysfunction; protective role ... See more keywords