Antitumor and antiangiogenic activity of the novel chimeric inhibitor animacroxam in testicular germ cell cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12582
Abstract: Chimeric inhibitors, which merge two drug pharmacophores in a single molecule have become a prominent approach for the design of novel anticancer compounds. Here, we examined animacroxam, which combines histone deacetylase (HDAC) inhibitory and cytoskeleton‐interfering… read more here.
Keywords: inhibitor; testicular germ; germ cell; cell ... See more keywords
Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12909
Abstract: Testicular germ cell tumors (TGCTs) are the most common cancers in men aged 15–39 years and are divided into two major groups, seminomas and nonseminomas. Novel treatment options are required for these patients, to limit… read more here.
Keywords: methylation; testicular germ; promoter methylation; germ cell ... See more keywords
Design, Synthesis, and Screening of Triazolopyrimidine–Pyrazole Hybrids as Potent Apoptotic Inducers
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201700137
Abstract: An efficient synthesis of novel 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐5,7‐dimethyl‐[1,2,4]triazolo[4,3‐a]‐pyrimidines was accomplished by the oxidation of pyrimidinylhydrazones by using organoiodine(III) reagent. All new triazolopyrimidine derivatives bearing the pyrazole scaffold were screened to evaluate them as a reproductive toxicant in… read more here.
Keywords: design synthesis; screening triazolopyrimidine; testicular germ; germ cells ... See more keywords
A nomogram for predicting survival and retroperitoneal lymph node dissection treatment in patients with resected testicular germ cell tumors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.25519
Abstract: To build nomogram incorporating potential prognostic factors for predicting survival outcomes of testicular germ cell tumors (TGCT) patients after resection of the primary tumor. read more here.
Keywords: testicular germ; cell tumors; predicting survival; germ cell ... See more keywords
Assessing Homologous Recombination and Interstrand Cross-Link Repair in Embryonal Carcinoma Testicular Germ Cell Tumor Cell Lines.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0860-9_9
Abstract: Testicular germ cell tumors (TGCTs) are typically exquisitely sensitive to DNA interstrand cross-link (ICLs) agents. ICLs covalently link both strands of the DNA duplex, impeding fundamental cellular processes like DNA replication to cause cell death.… read more here.
Keywords: cell lines; testicular germ; germ cell; recombination ... See more keywords
Expression of cellular apoptosis susceptibility (CAS) in the human testis and testicular germ cell tumors
Sign Up to like & getrecommendations! Published in 2019 at "Medical Oncology"
DOI: 10.1007/s12032-019-1281-1
Abstract: Testicular germ cell tumors are the most frequent malignancies found in men between 15 and 44 years old. Although cellular apoptosis susceptibility (CAS) was demonstrated to be upregulated in breast cancer and colon cancer, the expression… read more here.
Keywords: testicular germ; cell tumors; cas; germ cell ... See more keywords
Bilateral Testicular Germ Cell Tumors: A Case‐Series From a UK‐Based Tertiary Referral Center Over 19 Years
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Genitourinary Cancer"
DOI: 10.1016/j.clgc.2018.02.020
Abstract: Bilateral testicular germ cell tumors (TGCTs) are a rare occurrence, with a frequency in this series of 1.4% of all testicular cancer cases. However, patients with a diagnosis of TGCT have a vastly increased risk… read more here.
Keywords: bilateral testicular; testicular germ; case series; series ... See more keywords
Epigenetics and testicular germ cell tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.03.072
Abstract: Abstract Malignant testicular germ cell tumors (TGCTs) are the most frequent testicular cancers in Caucasian males, developing at the most productive age of man. We are briefly reviewing TGCT-tumorigenesis with an emphasis on epigenetics. Epigenetic… read more here.
Keywords: testicular germ; cell tumors; germ cell; epigenetics testicular ... See more keywords
Responses to genotoxicity in mouse testicular germ cells and epididymal spermatozoa are affected by increased age.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.04.013
Abstract: The increased number of cell divisions undergone by spermatogonia of older fathers cannot fully account for the observed increase in germline genetic damage. Studies have shown that the mechanisms induced in germ cells in response… read more here.
Keywords: age; testicular germ; epididymal spermatozoa; germ cells ... See more keywords
Mosaic chromosome Y loss and testicular germ cell tumor risk
Sign Up to like & getrecommendations! Published in 2017 at "Journal of human genetics"
DOI: 10.1038/jhg.2017.20
Abstract: Studies have suggested mosaic loss of chromosome Y (mLOY) in blood-derived DNA is common in older men. Cohort studies investigating mLOY and mortality have reported contradictory results. Previous work found that a 1.6 Mb deletion of… read more here.
Keywords: risk; testicular germ; germ cell; chromosome ... See more keywords
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor
Sign Up to like & getrecommendations! Published in 2017 at "Nature genetics"
DOI: 10.1038/ng.3879
Abstract: The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to… read more here.
Keywords: loci; genome wide; association studies; testicular germ ... See more keywords