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   Articles with "testicular toxicity" as a keyword



Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature

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recommendations! Published in 2023 at "Birth Defects Research"

DOI: 10.1002/bdr2.2160

Abstract: Based on new testing, we re‐assess U.S. EPA and California OEHHA conclusions regarding male reproductive toxicity associated with cyanide exposure. read more here.

Keywords: assessment new; cyanide assessment; testicular toxicity; toxicity cyanide ... See more keywords

Dimethyl Fumarate Protects Diabetes‐Induced Testicular Toxicity in Rats: Investigations on Nrf‐2/HO‐1 and β‐Catenin/OCT‐4 Signalling Pathways

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recommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.70209

Abstract: Type 1 Diabetes Mellitus (T1DM) is associated with the destruction of insulin‐producing β‐cells and is characterized by prolonged hyperglycemia. This can increase oxidative stress which eventually damages the male reproductive system, disturbs the production of… read more here.

Keywords: dimethyl fumarate; diabetes induced; induced testicular; testicular toxicity ... See more keywords

Di‐(2‐ethylhexyl) phthalate (DEHP)‐induced testicular toxicity through Nrf2‐mediated Notch1 signaling pathway in Sprague–Dawley rats

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recommendations! Published in 2018 at "Environmental Toxicology"

DOI: 10.1002/tox.22559

Abstract: Di‐(2‐ethylhexyl) phthalate (DEHP) is an environmental endocrine disruptor widely used in China that is harmful to the male reproductive system. Many studies have shown that DEHP causes testicular toxicity through oxidative stress, but the specific… read more here.

Keywords: dehp induced; testicular toxicity; toxicity; pathway ... See more keywords
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Sudachitin Alleviates Paraquat Instigated Testicular Toxicity in Albino Rats via Regulating Nrf‐2/Keap‐1, Inflammatory, Steroidogenic, and Histological Profile

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recommendations! Published in 2024 at "Environmental Toxicology"

DOI: 10.1002/tox.24408

Abstract: Paraquat (PQ) is a noxious herbicide which adversely affects the vital organs including male reproductive system. Sudachitin (SCN) is a naturally occurring flavonoid that demonstrates a wide range of biological potentials. The current study was… read more here.

Keywords: scn; inflammatory; factor; testicular toxicity ... See more keywords

Potential of sperm small non-coding RNAs as biomarkers of testicular toxicity in a doxorubicin-induced mouse model

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recommendations! Published in 2021 at "Biochemistry and Biophysics Reports"

DOI: 10.1016/j.bbrep.2021.101160

Abstract: Testicular toxicity is a major concern in cancer chemotherapy and drug development as it can result in infertility; however, there are no effective biomarkers for this adverse effect. To identify new biomarkers, we investigated the… read more here.

Keywords: coding rnas; testicular toxicity; small non; non coding ... See more keywords

Silver nanoparticles testicular toxicity in rat.

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recommendations! Published in 2019 at "Environmental toxicology and pharmacology"

DOI: 10.1016/j.etap.2019.103194

Abstract: To evaluate the potential testicular toxicity induced by silver nanoparticles (AgNPs) in Sprague Dawley rate. The protocol study was designed as follows: G1: 30 adult male rats were kept as control. G2: 30 adult male… read more here.

Keywords: significant decrease; testicular toxicity; adult male; silver nanoparticles ... See more keywords

Ethanolic extract of Moringa oleifera leaves alleviate cyclophosphamide-induced testicular toxicity by improving endocrine function and modulating cell specific gene expression in mouse testis.

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recommendations! Published in 2020 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2020.112922

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Moringa oleifera Lam. is known for its nutritional and ethno medicinal values due to the presence of wide array of phytochemicals with multiple biological activities. We have previously reported that ethanolic extract of… read more here.

Keywords: spermatogonial cells; moringa oleifera; testicular toxicity; expression ... See more keywords

Lack of beneficial effect of activated charcoal in lead induced testicular toxicity in male albino rats

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recommendations! Published in 2017 at "Middle East Fertility Society Journal"

DOI: 10.1016/j.mefs.2017.02.001

Abstract: Abstract Objective: Lead is a multi-organ toxicant implicated in various diseases including testicular toxicity. In search of cheap and readily available antidote this study has investigated a beneficial role of activated charcoal in lead induced… read more here.

Keywords: activated charcoal; testicular toxicity; induced testicular; lead ... See more keywords

Untargeted LC‐MS‐based metabonomics revealed that aristolochic acid I induces testicular toxicity by inhibiting amino acids metabolism, glucose metabolism, &bgr;‐oxidation of fatty acids and the TCA cycle in male mice

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recommendations! Published in 2019 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2019.04.014

Abstract: &NA; As the main toxic component of aristolochic acid, aristolochic acid I (AAI) is primarily found in Aristolochiaceae plants such as Aristolochia, Aristolochia fangchi and Caulis aristolochiae manshuriensis. AAI has been proven to be carcinogenic,… read more here.

Keywords: metabolism; fatty acids; testicular toxicity; acid ... See more keywords

Arrested Acetylene-Induced Pulmonary and Testicular Toxicity in Rats Through Treatment With Polyphenols

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recommendations! Published in 2022 at "Drug and Chemical Toxicology"

DOI: 10.1080/01480545.2022.2066115

Abstract: Abstract Occupational exposure to potentially harmful substances is one of the dangers associated with industrial jobs. This study evaluated the modulatory influence of selected dietary polyphenols on the pulmonotoxic and testiculotoxic effects of crude acetylene,… read more here.

Keywords: pulmonary testicular; testicular toxicity; induced pulmonary; arrested acetylene ... See more keywords

P-002 Acetate attenuates cyclophosphamide-induced testicular toxicity by modulating steroidogenic and apoptotic signaling via an oxidative stress-dependent pathway

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recommendations! Published in 2024 at "Human Reproduction"

DOI: 10.1093/humrep/deae108.382

Abstract: Will acetate therapy attenuate cyclophosphamide-induced testicular toxicity when used concomitantly? Acetate attenuated cyclophosphamide-induced testicular toxicity by modulating steroidogenic and apoptotic signaling via an oxidative stress-dependent pathway. Cyclophosphamide is an anthracycline that is effective in the… read more here.

Keywords: cyclophosphamide induced; testicular toxicity; acetate; induced testicular ... See more keywords