Mismatch Repair Deficiency Testing in Patients With Colorectal Cancer and Nonadherence to Testing Guidelines in Young Adults
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.3580
Abstract: Importance Mismatch repair (MMR) deficiency of DNA has been observed in up to 15% of sporadic colorectal cancers (CRCs) and is a characteristic feature of Lynch syndrome, which has a higher incidence in young adults… read more here.
Keywords: testing guidelines; deficiency testing; mmr deficiency; mismatch repair ... See more keywords
Updates in Genetic Testing Guidelines for Breast Cancer Susceptibility Genes: a Change in the Paradigm
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DOI: 10.1007/s12609-019-00339-x
Abstract: Up to 10% of all breast cancers are associated with inherited germline mutations. Genetic testing guidelines for hereditary breast cancer susceptibility have changed significantly since their inception in the late 1990s. The purpose of this… read more here.
Keywords: genetic testing; testing guidelines; breast; cancer susceptibility ... See more keywords
Underdiagnosis of Hereditary Breast Cancer: Are Genetic Testing Guidelines a Tool or an Obstacle?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.18.01631
Abstract: Purpose An estimated 10% of breast and ovarian cancers result from hereditary causes. Current testing guidelines for germ line susceptibility genes in patients with breast carcinoma were developed to identify carriers of BRCA1/2 variants and… read more here.
Keywords: genetic testing; cancer; breast cancer; cancer genetic ... See more keywords