Food‐grade titanium dioxide (E171) by solid or liquid matrix administration induces inflammation, germ cells sloughing in seminiferous tubules and blood‐testis barrier disruption in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3842
Abstract: Food‐grade titanium dioxide labeled as E171 has been approved for human consumption by the Food and Drug Administration (USA) and by the European Union for five decades. However, titanium dioxide has been classified as a… read more here.
Keywords: testis; blood testis; titanium dioxide; testis barrier ... See more keywords
Testin regulates the blood‐testis barrier via disturbing occludin/ZO‐1 association and actin organization
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29541
Abstract: The blood‐testis barrier (BTB) separates the seminiferous epithelium into the apical and basal compartments. The BTB has to operate timely and accurately to ensure the correct migration of germ cells, meanwhile maintaining the immunological barrier.… read more here.
Keywords: barrier; actin; testin rnai; blood testis ... See more keywords
Modulating the Blood-Testis Barrier Towards Increasing Drug Delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2020.07.002
Abstract: Testicular cells produce several biologically active peptides that exert their downstream effects by activating distinct signaling proteins. These biomolecules are now known to support spermatogenesis and effectively enhance paracellular and transcellular diffusion of drugs (e.g.,… read more here.
Keywords: tissue barriers; blood testis; blood; testis barrier ... See more keywords
Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model.
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DOI: 10.1021/acsnano.1c10029
Abstract: Sperm motility can be enhanced by adding ATP exogenously during in vitro fertilization. However, administering exogenous ATP to the testis to improve sperm motility for in vivo asthenozoospermia treatment has not been investigated yet. Inspired… read more here.
Keywords: blood testis; testis barrier; sperm motility; asthenozoospermia ... See more keywords
Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier
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DOI: 10.1124/dmd.121.000748
Abstract: The blood-testis barrier (BTB) is formed by basal tight junctions between adjacent Sertoli cells (SCs) of the seminiferous tubules and acts as a physical barrier to protect developing germ cells in the adluminal compartment from… read more here.
Keywords: blood testis; localization; btb; barrier ... See more keywords
Matrix metalloproteinase 9 facilitates Zika virus invasion of the testis by modulating the integrity of the blood-testis barrier
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008509
Abstract: Zika virus (ZIKV) is a unique flavivirus with high tropism to the testes. ZIKV can persist in human semen for months and can cause testicular damage in male mice. However, the mechanisms through which ZIKV… read more here.
Keywords: testis; mmp9; matrix metalloproteinase; blood testis ... See more keywords
FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization via its effect on Arp3 in the mouse testis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.915274
Abstract: FYN is a non-receptor tyrosine kinase of the SRC family that facilitates virus entry across epithelial tight junctions. However, the role of FYN in mammalian testes in maintaining the blood-testis barrier (BTB) integrity and the… read more here.
Keywords: blood testis; ectoplasmic specialization; fyn; apical ectoplasmic ... See more keywords
Bibliometric and visual analysis of blood-testis barrier research
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.969257
Abstract: Background: Extensive research on the blood-testis barrier has been undertaken in recent years. However, no systematic bibliometric study has been conducted on this subject. Our research aimed to identify the hotspots and frontiers of blood-testis… read more here.
Keywords: blood testis; testis barrier; research;
Blood Testis Barrier and Somatic Cells Impairment in a Series of 35 Adult Klinefelter Syndrome Patients
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20225717
Abstract: Klinefelter Syndrome (KS) is the most common genetic cause of infertility in men. Degeneration of the testicular tissue starts in utero and accelerates at puberty with hyalinisation of seminiferous tubules, spermatogonia apoptosis and germ cell… read more here.
Keywords: klinefelter syndrome; syndrome patients; blood testis; testis barrier ... See more keywords
Apocynin Ameliorates Monosodium Glutamate Induced Testis Damage by Impaired Blood-Testis Barrier and Oxidative Stress Parameters
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13030822
Abstract: Background: the aim of this study was to investigate the effects of apocynin (APO) on hormone levels, the blood-testis barrier, and oxidative biomarkers in monosodium glutamate (MSG) induced testicular degeneration. Methods: Sprague Dawley male rats… read more here.
Keywords: blood testis; barrier oxidative; msg; testis ... See more keywords