Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis‐Specific Serine/Threonine Kinase 2 (TSSK2)
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DOI: 10.1002/cmdc.201700503
Abstract: Testis‐specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. A high‐throughput screen of ≈17 000 compounds using a mobility shift assay identified two potent series of inhibitors having a pyrrolopyrimidine or pyrimidine core.… read more here.
Keywords: specific serine; serine threonine; kinase; pyrimidine ... See more keywords
Testis‐specific isoform of angiotensin‐converting enzyme (tACE) is involved in the regulation of bovine sperm capacitation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22790
Abstract: We hypothesized that the testis‐specific isoform of angiotensin‐converting enzyme (tACE) is released during bovine sperm capacitation, and its peptidase activity is required for capacitation. Specific objectives of this study were to (i) develop an anti‐tACE… read more here.
Keywords: bovine sperm; sperm capacitation; tace; specific isoform ... See more keywords
Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2016.12.065
Abstract: Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene… read more here.
Keywords: h3t; testis specific; h3t gene; variant h3t ... See more keywords
Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1)
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30115-3
Abstract: Expression of a constitutively active Rho A (V14Rho) in podocytes in vivo induces albuminuria and foot process (FP) effacement. These effects may be mediated by the Rho A effector Rho kinase (ROK); but inhibition of… read more here.
Keywords: specific kinase; cfl1; kinase; testis specific ... See more keywords
Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac146
Abstract: Abstract Serine proteases (PRSS) constitute nearly one-third of all proteases, and many of them have been identified to be testis-specific and play significant roles during sperm development and male reproduction. PRSS54 is one of the… read more here.
Keywords: localization; prss54; acrosomal granule; testis specific ... See more keywords
Testis‐specific calcium‐binding protein CBP86‐IV (CABYR) binds with phosphoglycerate kinase 2 in vitro and in vivo experiment
Sign Up to like & getrecommendations! Published in 2019 at "Andrologia"
DOI: 10.1111/and.13287
Abstract: The investigation of the interacting proteins with testis‐specific calcium‐binding protein CBP86‐IV (CABYR) was carried out in human spermatozoa. The total RNA from human spermatozoa was extracted, and the ORF sequence of TSCBP86‐IV gene was amplified… read more here.
Keywords: protein; calcium binding; cbp86; testis specific ... See more keywords
Testis-specific protein Y-encoded 1 regulates androgen receptor expression through the MAPK/ERK pathway in male hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Saudi medical journal"
DOI: 10.15537/smj.2022.43.10.20220455
Abstract: OBJECTIVES To analyze the mechanism of testis-specific protein Y-encoded 1 (TSPY1) in male hepatocellular carcinoma (HCC). METHODS This experimental study was carried out at Guangxi Medical University's First Affiliated Hospital, Guangxi, China, between January 2016… read more here.
Keywords: specific protein; testis specific; expression; protein encoded ... See more keywords
Heterogeneity in the Epigenetic Landscape of Murine Testis-Specific Histone Variants TH2A and TH2B Sharing the Same Bi-Directional Promoter
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DOI: 10.3389/fcell.2021.755751
Abstract: Testis-specific histone variants are crucial to promote open chromatin structure to enable nucleosome disassembly in the final stages of spermiogenesis. However, even after histone replacement, mature sperm retain a proportion of these variants, the function… read more here.
Keywords: th2a th2b; th2b th2a; th2a; testis specific ... See more keywords
Evolution of a New Testis-Specific Functional Promoter Within the Highly Conserved Map2k7 Gene of the Mouse
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.812139
Abstract: Map2k7 (synonym Mkk7) is a conserved regulatory kinase gene and a central component of the JNK signaling cascade with key functions during cellular differentiation. It shows complex transcription patterns, and different transcript isoforms are known… read more here.
Keywords: promoter; map2k7 gene; highly conserved; testis specific ... See more keywords