Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis‐Specific Serine/Threonine Kinase 2 (TSSK2)
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DOI: 10.1002/cmdc.201700503
Abstract: Testis‐specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. A high‐throughput screen of ≈17 000 compounds using a mobility shift assay identified two potent series of inhibitors having a pyrrolopyrimidine or pyrimidine core.… read more here.
Keywords: specific serine; serine threonine; kinase; pyrimidine ... See more keywords
Testis‐specific isoform of angiotensin‐converting enzyme (tACE) is involved in the regulation of bovine sperm capacitation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22790
Abstract: We hypothesized that the testis‐specific isoform of angiotensin‐converting enzyme (tACE) is released during bovine sperm capacitation, and its peptidase activity is required for capacitation. Specific objectives of this study were to (i) develop an anti‐tACE… read more here.
Keywords: bovine sperm; sperm capacitation; tace; specific isoform ... See more keywords
Structural insights into the interaction between testis‐specific Y‐encoded‐like protein 5 and ubiquitin‐specific protease 7
Sign Up to like & getrecommendations! Published in 2025 at "Protein Science"
DOI: 10.1002/pro.70116
Abstract: The Alternative Lengthening of Telomeres (ALT) mechanism enables telomere maintenance, contributing to the immortality of certain cancer cells. Disrupting the interaction between testis‐specific Y‐encoded‐like protein 5 (TSPYL5) and ubiquitin‐specific protease 7 (USP7) has emerged as… read more here.
Keywords: tspyl5; encoded like; testis specific; specific encoded ... See more keywords
TPCA-1 compound, inhibiting testis-specific serine/threonine protein kinase 3 for potential male sterile in Bombyx mori.
Sign Up to like & getrecommendations! Published in 2024 at "Pest management science"
DOI: 10.1002/ps.8347
Abstract: BACKGROUND Protein kinases are a type of transferase enzyme that catalyze the phosphorylation of protein substrates, including receptor proteins. Testis-specific serine/threonine kinases (TSSKs) are a highly conserved group of protein kinases found in various organisms.… read more here.
Keywords: bombyx mori; serine threonine; testis specific; protein ... See more keywords
Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.
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DOI: 10.1016/j.celrep.2016.12.065
Abstract: Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene… read more here.
Keywords: h3t; testis specific; h3t gene; variant h3t ... See more keywords
Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1)
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30115-3
Abstract: Expression of a constitutively active Rho A (V14Rho) in podocytes in vivo induces albuminuria and foot process (FP) effacement. These effects may be mediated by the Rho A effector Rho kinase (ROK); but inhibition of… read more here.
Keywords: specific kinase; cfl1; kinase; testis specific ... See more keywords
Loss-of-function in testis-specific serine/threonine protein kinase triggers male infertility in an invasive moth
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DOI: 10.1038/s42003-024-06961-5
Abstract: Genetic biocontrol technologies present promising and eco-friendly strategies for the management of pest and insect-transmitted diseases. Although considerable advancements achieve in gene drive applications targeting mosquitoes, endeavors to combat agricultural pests have been somewhat restricted.… read more here.
Keywords: threonine protein; serine threonine; threonine; protein kinase ... See more keywords
Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac146
Abstract: Abstract Serine proteases (PRSS) constitute nearly one-third of all proteases, and many of them have been identified to be testis-specific and play significant roles during sperm development and male reproduction. PRSS54 is one of the… read more here.
Keywords: localization; prss54; acrosomal granule; testis specific ... See more keywords
Testis-specific H2B.W1 disrupts nucleosome integrity by reducing DNA–histone interactions
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DOI: 10.1093/nar/gkae825
Abstract: Abstract Multiple testis-specific histone variants are involved in the dynamic chromatin transitions during spermatogenesis. H2B.W1 (previously called H2BFWT) is an H2B variant specific to primate testis with hitherto unclear functions, although its single-nucleotide polymorphisms (SNPs)… read more here.
Keywords: h2b disrupts; testis specific; specific h2b; h2b ... See more keywords
Testis‐specific calcium‐binding protein CBP86‐IV (CABYR) binds with phosphoglycerate kinase 2 in vitro and in vivo experiment
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DOI: 10.1111/and.13287
Abstract: The investigation of the interacting proteins with testis‐specific calcium‐binding protein CBP86‐IV (CABYR) was carried out in human spermatozoa. The total RNA from human spermatozoa was extracted, and the ORF sequence of TSCBP86‐IV gene was amplified… read more here.
Keywords: protein; calcium binding; cbp86; testis specific ... See more keywords
Ectopic expression of testis-specific transcription elongation factor in driving cancer
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DOI: 10.1126/sciadv.ads4200
Abstract: The testis-specific BET protein BRDT structurally resembles the ubiquitous BRD4 and is misexpressed in cancer, and we show that BRDT misexpression may affect lung cancer progression. BRDT knockdown in lung cancer cells slowed tumor growth… read more here.
Keywords: cancer; testis specific; ectopic expression; brdt ... See more keywords