Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6β-Hydroxylation
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DOI: 10.1124/dmd.120.000261
Abstract: CYP3A4 is among the most abundant liver and intestinal drug-metabolizing cytochrome P450 enzymes, contributing to the metabolism of more than 30% of clinically used drugs. Therefore, interindividual variability in CYP3A4 activity is a frequent cause… read more here.
Keywords: testosterone hydroxylation; hydroxylation; drug; cyp3a4 variants ... See more keywords