Bisphenol S induces oxidative stress‐mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO‐1 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23273
Abstract: Bisphenol S (BPS) is an environmental endocrine disruptor widely used in industrial production. BPS induces oxidative stress and exhibits male reproductive toxicity in mice, but the mechanisms by which BPS impairs steroid hormone synthesis are… read more here.
Keywords: nrf2 signaling; oxidative stress; testosterone synthesis; synthesis ... See more keywords
DNA methylation‐mediated inhibition of MGARP is involved in impaired progeny testosterone synthesis in mice exposed to DBP in utero
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23734
Abstract: The dibutyl phthalate (DBP) has been detected in fetuses and infants and can cause damage to the reproductive system in adulthood, but the exact mechanism remains unclear. Here, we aim to investigate the effects of… read more here.
Keywords: methylation; dbp; involved impaired; testosterone synthesis ... See more keywords
Selenium nanoparticles improve nickel-induced testosterone synthesis disturbance by down-regulating miR-708-5p/p38 MAPK pathway in Leydig cells.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23811
Abstract: The present study was designed to investigate the role of miR-708-5p/p38 mitogen-activated protein kinase (MAPK) pathway during the mechanism of selenium nanoparticles (Nano-Se) against nickel (Ni)-induced testosterone synthesis disorder in rat Leydig cells. We conducted… read more here.
Keywords: mir 708; leydig cells; p38 mapk; testosterone synthesis ... See more keywords
Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2022.115969
Abstract: Icariin (ICA), extracted from Epimedium, is a flavonoid used in traditional Chinese medicine. Di(2-ethylhexyl) phthalate (DEHP) is a phthalate used in commercial products as a plasticizer that can influence the human endocrine and reproduction system.… read more here.
Keywords: testosterone synthesis; akt creb; leydig; creb ... See more keywords
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2110126
Abstract: Abstract Context Bushen Yiyuan recipe (BYR) is an effective Chinese prescription with antifatigue and antioxidation effects. Objective The effects of BYR on testosterone synthesis in rat Leydig cells with exercise-induced low serum testosterone levels (EILST)… read more here.
Keywords: serum testosterone; synthesis; testosterone; testosterone synthesis ... See more keywords
HIF 1 inhibits StAR transcription and testosterone synthesis in murine Leydig cells.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-18-0148
Abstract: Hypoxia-inducible factor-1 (HIF1) is a critical transcription factor involved in cell response to hypoxia. Under physiological conditions, its a subunit is rapidly degraded in most tissues except testes. HIF1 is stably expressed in Leydig cells,… read more here.
Keywords: transcription; testosterone; testosterone synthesis; leydig cells ... See more keywords
The Effect and Mechanism of GRIM-19 on Mouse Sperm Quality and Testosterone Synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-21-0385
Abstract: Abnormal sperm parameters such as oligospermia, asthenospermia, and teratozoospermia result in male factor infertility. Previous studies have shown that mitochondria play an important role in human spermatozoa motility. But the related pathogenesis is far from… read more here.
Keywords: grim mouse; synthesis; grim mice; testosterone synthesis ... See more keywords
Hypoxia reduces testosterone synthesis in mouse Leydig cells by inhibiting NRF1-activated StAR expression
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14842
Abstract: Male fertility disorders play a key role in half of all infertility cases. Reduction in testosterone induced by hypoxia might cause diseases in reproductive system and other organs. Hypoxic exposure caused a significant decrease of… read more here.
Keywords: hypoxia; expression; testosterone synthesis; leydig cells ... See more keywords
CeO2NPs relieve radiofrequency radiation, improve testosterone synthesis, and clock gene expression in Leydig cells by enhancing antioxidation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s206561
Abstract: Introduction: The ratio of Ce3+/Ce4+ in their structure confers unique functions on cerium oxide nanoparticles (CeO2NPs) containing rare earth elements in scavenging free radicals and protecting against oxidative damage. The potential of CeO2NPs to protect… read more here.
Keywords: expression; testosterone synthesis; leydig cells; ceo2nps ... See more keywords
Natural Astaxanthin Improves Testosterone Synthesis and Sperm Mitochondrial Function in Aging Roosters
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11091684
Abstract: Spermatogenesis, sperm motility, and apoptosis are dependent on the regulation of glandular hormones and mitochondria. Natural astaxanthin (ASTA) has antioxidant, anti-inflammatory, and anti-apoptotic properties. The present study evaluates the effects of ASTA on testosterone synthesis… read more here.
Keywords: function aging; aging roosters; mitochondrial function; synthesis ... See more keywords
Per1/Per2 Disruption Reduces Testosterone Synthesis and Impairs Fertility in Elderly Male Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137399
Abstract: Circadian rhythm disorders caused by genetic or environmental factors lead to decreased male fertility but the mechanisms are poorly understood. The current study reports that the mechanism of Per1/Per2 Double knockout (DKO) reduced the reproductive… read more here.
Keywords: fertility; per1 per2; testosterone synthesis; mice ... See more keywords