Diagnostics for Pleiotropy in Mendelian Randomization Studies: Global and Individual Tests for Direct Effects
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DOI: 10.1093/aje/kwy177
Abstract: Diagnosing pleiotropy is critical for assessing the validity of Mendelian randomization (MR) analyses. The popular MR-Egger method evaluates whether there is evidence of bias-generating pleiotropy among a set of candidate genetic instrumental variables. In this… read more here.
Keywords: tests direct; pleiotropy; individual tests; mendelian randomization ... See more keywords