TET2 in Normal and Malignant Hematopoiesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a026518
Abstract: The ten-eleven translocation (TET) family of enzymes were originally cloned from the translocation breakpoint of t(10;11) in infant acute myeloid leukemia (AML) with subsequent genomic analyses revealing somatic mutations and suppressed expression of TET family… read more here.
Keywords: hematopoiesis; tet family; tet2 normal; normal malignant ... See more keywords
Dysregulation of the TET family of epigenetic regulators in hematopoietic malignancies.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019791475
Abstract: DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation and cancer. Cancer cells display highly dysregulated DNA methylation profiles characterized by global hypomethylation in conjunction with hypermethylation of promoter… read more here.
Keywords: epigenetic regulators; tet family; family epigenetic; dysregulation tet ... See more keywords