Articles with "tet mediated" as a keyword



Photo by nci from unsplash

TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.

Sign Up to like & get
recommendations!
Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.03.022

Abstract: Loss-of-function mutations in the SDHB subunit of succinate dehydrogenase predispose patients to aggressive tumors characterized by pseudohypoxic and hypermethylator phenotypes. The mechanisms leading to DNA hypermethylation and its contribution to SDH-deficient cancers remain undemonstrated. We examine the… read more here.

Keywords: sdh deficient; hypermethylation; mediated hypermethylation; tet mediated ... See more keywords