Hydroxyurea promotes TET1 expression and induces apoptosis in osteosarcoma cells
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DOI: 10.1042/bsr20190456
Abstract: Ten-eleven translocation (TET) proteins are abnormally expressed in various cancers. Osteosarcoma cells were treated with hydroxyurea to investigate the expression pattern of TET proteins in these cells. The expression of TET1 was increased in U2OS… read more here.
Keywords: expression; osteosarcoma cells; tet1 expression; apoptosis ... See more keywords
Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205626119
Abstract: Significance The β3-adrenergic receptor (β3-AR) is a major regulator of energy expenditure that triggers lipolysis and thermogenesis in adipose tissue, thereby significantly attenuating the risk of obesity. Obesity is associated with diminished β3-AR expression and… read more here.
Keywords: adipose tet; loss adipose; expression; tet proteins ... See more keywords
Deciphering the multifaceted roles of TET proteins in T‐cell lineage specification and malignant transformation
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DOI: 10.1111/imr.12940
Abstract: TET proteins are DNA demethylases that can oxidize 5‐methylcytosine (5mC) to generate 5‐hydroxymethylcytosine (5hmC) and other oxidized mC bases (oxi‐mCs). Importantly, TET proteins govern cell fate decisions during development of various cell types by activating… read more here.
Keywords: cell lineage; tet proteins; proteins cell; lineage specification ... See more keywords
TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.940995
Abstract: TET proteins mediate DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and other oxidative derivatives. We have previously demonstrated a dynamic enrichment of 5hmC during T and invariant natural killer T cell lineage specification. Here,… read more here.
Keywords: tet proteins; cell; lineage specification;