Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by &agr;-Ketoglutarate and TET-TDG Functional Reactivation
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DOI: 10.1161/circresaha.117.311300
Abstract: Rationale: Human cardiac mesenchymal cells (CMSCs) are a therapeutically relevant primary cell population. Diabetes mellitus compromises CMSC function as consequence of metabolic alterations and incorporation of stable epigenetic changes. Objective: To investigate the role of… read more here.
Keywords: dna; tet tdg; agr ketoglutarate; cardiac mesenchymal ... See more keywords