Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02290-w
Abstract: Effective therapy of acute myeloid leukemia (AML) remains an unmet need. DNA methylcytosine dioxygenase Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Through a series of data analysis and drug screening, we identified… read more here.
Keywords: nsc 370284; myeloid leukemia; acute myeloid; tet1 ... See more keywords
TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23735-3
Abstract: The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and… read more here.
Keywords: tet1; myelin repair; dna hydroxymethylation;
Developmental epigenetic programming by Tet1/3 determines peripheral CD8 T cell fate
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Reports"
DOI: 10.1038/s44319-025-00439-z
Abstract: In response to infections, naive CD8 T cells give rise to effector and memory T cells. However, eliciting long-lived memory CD8 T cells remains a challenge for many infections. DNA demethylation of cytosines within CpG… read more here.
Keywords: cd8; tet1; effector; effector memory ... See more keywords
TET1 exerts its tumour suppressor function by regulating autophagy in glioma cells
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20160523
Abstract: DNA methylation and demethylation play a critical role in the regulation of the molecular pathogenesis of gliomas. Tet methylcytosine dioxygenase 1 (TET1) catalyses the sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine, (5hmC) leading to eventual… read more here.
Keywords: glioma; u251 cells; tumour suppressor; expression tet1 ... See more keywords
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116251119
Abstract: Significance This study shows that Fragile X mental retardation protein (FMRP) promotes messenger RNA (mRNA)-dependent recombination via facilitating ten-eleven translocation protein 1 (TET1)-mediated mRNA methyl-5-cytosine (m5C) demethylation. Loss of FMRP leads to damage induced mRNA… read more here.
Keywords: tet1; recombination; demethylation; fmrp ... See more keywords
The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac089
Abstract: Abstract Tet enzymes (Tet1/2/3) oxidize 5-methylcytosine to promote DNA demethylation and partner with chromatin modifiers to regulate gene expression. Tet1 is highly expressed in embryonic stem cells (ESCs), but its enzymatic and non-enzymatic roles in… read more here.
Keywords: tet1; dna; embryonic stem; catalytic activity ... See more keywords
Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad231
Abstract: Gastrulation begins when the epiblast forms the primitive streak or becomes definitive ectoderm. During this lineage bifurcation, the DNA dioxygenase TET1 has bipartite functions in transcriptional activation and repression, but the mechanisms remain unclear. By… read more here.
Keywords: tet1; dual functions; genomic context; lineage bifurcation ... See more keywords
TET1 inhibits liver fibrosis by blocking hepatic stellate cell activation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16443
Abstract: Hepatic stellate cells (HSCs) are critical regulator contributing to the onset and progression of liver fibrosis. Chronic liver injury triggers HSCs to undergo vast changes and transâdifferentiation into a myofibroblast HSCs, the mechanism remains to… read more here.
Keywords: tet1; liver fibrosis; hepatic stellate; activation ... See more keywords
Microrna-29a Involvement in Phenotypic Transformation of Venous Smooth Muscle Cells via Tet1 in Response to Mechanical Cyclic Stretch.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4044581
Abstract: Mechanical stimuli play an important role in vein graft restenosis and the abnormal migration and proliferation of vascular smooth muscle cells (VSMCs) are pathological processes contributing to this disorder. Here, based on previous high throughput… read more here.
Keywords: phenotypic transformation; stretch; mir 29a; smooth muscle ... See more keywords
Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq8513
Abstract: Although the overall survival rate of B cell acute lymphoblastic leukemia (B-ALL) in childhood is more than 80%, it is merely 30% in refractory/relapsed and adult patients with B-ALL. This demonstrates a need for improved… read more here.
Keywords: tet1; cell; leukemia; lymphoblastic leukemia ... See more keywords
Liver TET1 promotesmetabolic dysfunction-associated steatotic liver disease by upregulating CD36
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.0914
Abstract: Background and Aims: The formation of 5-hydroxymethylcytosine catalyzed by the ten-eleven translocation (TET) methylcytosine dioxygenases is related to DNA demethylation and has been found decreased in human chronic liver diseases, including the metabolic dysfunction-associated steatotic… read more here.
Keywords: tet1; masld progression; physiology; liver ... See more keywords