OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development
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DOI: 10.7554/elife.34870
Abstract: TET enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine and higher oxidized derivatives. TETs stably associate with and are post-translationally modified by the nutrient-sensing enzyme OGT, suggesting a connection between metabolism and the epigenome. Here, we show for… read more here.
Keywords: function development; tet1 activity; ogt; tet1 ... See more keywords