Novel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25965
Abstract: CpG methylation of DNA takes part in a specific epigenetic memory that plays crucial roles in the differentiation and abnormality of the cells. The methylation pattern aberration of genomes is affected in three ways, namely… read more here.
Keywords: rpe cells; methylation; tet1 tet2; hypoxia pathway ... See more keywords
TET-mediated hydroxymethylcytosine at the Pparγ locus is required for initiation of adipogenic differentiation
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Obesity"
DOI: 10.1038/ijo.2017.8
Abstract: Background/Objectives:Adipose tissue is one of the main organs regulating energy homeostasis via energy storage as well as endocrine function. The adipocyte cell number is largely determined by adipogenesis. While the molecular mechanism of adipogenesis has… read more here.
Keywords: tet1 tet2; adipogenesis; expression; tet ... See more keywords
Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker
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DOI: 10.26508/lsa.201900516
Abstract: Expression of TET proteins in pluripotent cell types is visualised by epitope tagging of endogenous alleles. Tet1, Tet2, and Tet3 encode DNA demethylases that play critical roles during stem cell differentiation and reprogramming to pluripotency.… read more here.
Keywords: epitope tagging; tet1 tet2; pluripotency; expression ... See more keywords
Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00045
Abstract: The function of 5-hydroxymethylcytosine (5hmC) is poorly understood. 5hmC is an epigenetic modification of DNA, resulting from the oxidation of 5-methylcytosine (5mC) by the Fe2+, and 2-oxoglutarate-dependent, 10–11 translocation methylcytosine dioxygenases (TET1, TET2, and TET3).… read more here.
Keywords: tet2 expression; exercise; aged mice; tet1 tet2 ... See more keywords