TET2 missense variants in human neoplasia. A proposal of structural and functional classification
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.772
Abstract: The human TET2 gene plays a pivotal role in the epigenetic regulation of normal and malignant hematopoiesis. Somatic TET2 mutations have been repeatedly identified in age‐related clonal hematopoiesis and in myeloid neoplasms ranging from acute… read more here.
Keywords: missense variants; tet2; structural functional; variants human ... See more keywords
Tet2 regulates Barx2 expression in undifferentiated and early differentiated mouse embryonic stem cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.09.095
Abstract: The methylcytosine oxidase TET proteins play important roles in DNA demethylation and development. In developing embryos, TET2 are upregulated during pre-implantation development, and significantly expressed in the trophectoderm and inner cell mass. In this study,… read more here.
Keywords: barx2 expression; tet2; expression; mouse embryonic ... See more keywords
Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.02.001
Abstract: SUMMARY Restoring adult stem cell function provides an exciting approach for rejuvenating the aging brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive. Here we report that the enzyme ten eleven translocation methylcytosine dioxygenase 2… read more here.
Keywords: adult; age related; tet2; rescues age ... See more keywords
AMPK Regulates the Epigenome through Phosphorylation of TET2.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.09.015
Abstract: Emerging evidence suggests that changes to cellular metabolism can regulate epigenetic modifications to alter gene expression. Recently in Nature, Wu et al. show that the metabolic regulator AMPK can phosphorylate and thus stabilize the epigenetic modifying… read more here.
Keywords: metabolism; tet2; regulates epigenome; phosphorylation tet2 ... See more keywords
Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.117101
Abstract: AIMS Ten-eleven-translocation (Tet) proteins are 5-methylcytosine oxidases and have profound impact on DNA methylation and genes expression. This study aimed to investigate the role of Tet2 and its association with Foxp3 DNA methylation in regulatory… read more here.
Keywords: treg cells; methylation; foxp3 tsdr; tet2 ... See more keywords
TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101755
Abstract: The discovery of the Ten-Eleven Translocation (TET) protein family was initiated by the identification of the MLL partner TET1, and of mutations in the TET2 gene in hematological malignancies including myeloproliferative neoplasms (MPN). TET1, 2… read more here.
Keywords: tet2; reprogramming induced; pluripotent stem; induced pluripotent ... See more keywords
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.
Sign Up to like & getrecommendations! Published in 2018 at "Cell stem cell"
DOI: 10.1016/j.stem.2018.07.018
Abstract: Myelodysplastic syndrome (MDS), a largely incurable hematological malignancy, is derived from aberrant clonal hematopoietic stem/progenitor cells (HSPCs) that persist after conventional therapies. Defining the mechanisms underlying MDS HSPC maintenance is critical for developing MDS therapy.… read more here.
Keywords: sirt1; sirt1 activation; tet2; myelodysplastic syndrome ... See more keywords
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0125-z
Abstract: Somatic mutations in tet methylcytosinedioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies1–7. In both humans and mice, TET2 deficiency leads to increased self-renewal of haematopoietic stem cells with… read more here.
Keywords: pre leukaemic; tet2; pmp; microbial signals ... See more keywords
Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01220-9
Abstract: Loss-of-function TET2 mutations ( TET2 MT ) are common in myeloid neoplasia. TET2, a DNA dioxygenase, requires 2-oxoglutarate and Fe(II) to oxidize 5-methylcytosine. TET2 MT thus result in hypermethylation and transcriptional repression. Ascorbic acid (AA)… read more here.
Keywords: dependent effects; ascorbic acid; tet2; activity ... See more keywords
Macrophage migration inhibitory factor is overproduced through EGR1 in TET2low resting monocytes
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03057-w
Abstract: Somatic mutation in TET2 gene is one of the most common clonal genetic events detected in age-related clonal hematopoiesis as well as in chronic myelomonocytic leukemia (CMML). In addition to being a pre-malignant state, TET2… read more here.
Keywords: tet2; macrophage migration; inhibitory factor; migration inhibitory ... See more keywords
TET2 as a tumor suppressor and therapeutic target in T-cell acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2110758118
Abstract: Significance Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy in need of novel targeted therapies to prevent relapse and lessen treatment toxicity. We reveal frequent (∼88%) transcriptional silencing or repression of the tumor… read more here.
Keywords: cell acute; lymphoblastic leukemia; tet2; acute lymphoblastic ... See more keywords