Tet2-deficency in immune cells exacerbates tumor progression by increasing angiogenesis in a lung cancer model.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer science"
DOI: 10.1111/cas.15165
Abstract: Immune cells harboring somatic mutations reportedly infiltrate cancer tissues in patients with solid cancers and accompanying clonal hematopoiesis. Loss-of-function TET2 mutations are frequently observed in clonal hematopoiesis in solid cancers. Here, we evaluated activity of… read more here.
Keywords: tet2 deficient; lung cancer; cancer; immune cells ... See more keywords
Butyrate ameliorates Tet2-deficient clonal hematopoiesis phenotypes driven by high B12-induced gut dysbiosis.
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DOI: 10.1182/blood-2025-3173
Abstract: Introduction: Recent studies have linked elevated vitamin B12 serum levels with the presence of clonal hematopoiesis (CH) and an increased risk of developing myeloid malignancy. Excess B12 supplementation increases serum levels, alters gut microbial composition,… read more here.
Keywords: supplementation; b12 induced; tet2 deficient; butyrate ... See more keywords
An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis.
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DOI: 10.1182/blood.2024028033
Abstract: TET2 is among the most commonly mutated genes in both clonal hematopoiesis and myeloid malignancies, thus, the ability to identify selective dependencies in TET2 deficient cells has broad translational significance. Here, we identify regulators of… read more here.
Keywords: cas9 screen; hematopoiesis; tet2 deficient; tet2 ... See more keywords
B-cell tumor development in Tet2-deficient mice.
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DOI: 10.1182/bloodadvances.2017014118
Abstract: The TET2 gene encodes an α-ketoglutarate-dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. TET2 is frequently mutated in myeloid malignancies but also in B- and T-cell malignancies.… read more here.
Keywords: tet2 deficient; deficient mice; cell; tet2 ... See more keywords