TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors
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DOI: 10.1158/0008-5472.can-20-3761
Abstract: TET2 and DNMT3A mutations affect distinct DNA repair mechanisms and govern the differential sensitivities of oncogenic tyrosine kinase–positive leukemia cells to PARP inhibitors. Somatic variants in TET2 and DNMT3A are founding mutations in hematological malignancies… read more here.
Keywords: dna repair; tet2; tet2 dnmt3a; dnmt3a mutations ... See more keywords