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   Articles with "tet2 mutant" as a keyword



A Therapeutic Strategy for Preferential Targeting of TET2-Mutant and TET Dioxygenase-Deficient Cells in Myeloid Neoplasms.

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recommendations! Published in 2021 at "Cancer discovery"

DOI: 10.1158/2643-3230.bcd-20-0173

Abstract: TET2 is frequently mutated in myeloid neoplasms. Genetic TET2 deficiency leads to skewed myeloid differentiation and clonal expansion, but minimal residual TET activity is critical for survival of neoplastic progenitor and stem cells. Consistent with… read more here.

Keywords: myeloid neoplasms; tet2 mutant; tet dioxygenase; tet2 ... See more keywords

HMGA1 chromatin regulator induces inflammatory signals and promotes atherogenesis in Tet2 mutant clonal hematopoiesis

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-3177

Abstract: Clonal hematopoiesis (CH) is common with aging and associated with an increased risk for atherosclerosis (AS) and other cardiovascular diseases (CVD), although molecular mechanisms underlying atherogenesis in CH are only beginning to emerge. TET2 is… read more here.

Keywords: hmga1 chromatin; hmga1; clonal hematopoiesis; tet2 mutant ... See more keywords

Interleukin-12 and TNFα signaling drives parallel evolution of independent leukemic clones in JAK2V617F mutant myeloproliferative neoplasms

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-5538

Abstract: Progression from chronic phase myeloproliferative neoplasm (MPN) to secondary acute myeloid leukemia (sAML) is a poorly understood, severe complication traditionally linked to additional mutations in the MPN driver clone in genes such as TET2 and… read more here.

Keywords: jak2 mutant; tnf; jak2; tet2 mutant ... See more keywords

TET2-mutant clonal hematopoiesis and risk of gout

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recommendations! Published in 2022 at "Blood"

DOI: 10.1182/blood.2022015384

Abstract: Gout is a common inflammatory arthritis defined by NLRP3 inflammasome– and IL1β-dependent innate immune responses to monosodium urate (MSU) crystals. Agrawal et al identified clonal hematopoiesis of indeterminate potential (CHIP) as a risk factor for… read more here.

Keywords: tet2 mutant; gout; risk; mutant clonal ... See more keywords