Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-22-0846
Abstract: Transgenic knockin mice expressing a common loss-of-function mutation in human TET2 exhibit aging-related accelerated myeloid leukemia development and skewing of myelopoiesis toward the production of proinflammatory MHC-IIhi monocytes that may contribute to disease. See related… read more here.
Keywords: dangerous liaisons; inflammatory monocytes; liaisons tet2; tet2 mutation ... See more keywords
The Role of TET2 Mutation in Patients with Myeloproliferative Neoplasms and Thrombosis in Unusual Sites (Splanchnic Thrombosis and Cerebral Thrombosis)
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-207881
Abstract: Introduction: Myeloproliferative neoplasms (MPNs) associated with unusual site thrombosis (UST) exhibit a distinct clinical profile, particularly in cases of splanchnic vein thrombosis (SVT) and cerebral vein thrombosis (CVT), requiring meticulous interdisciplinary collaboration. This study aims… read more here.
Keywords: tet2 mutation; myeloproliferative neoplasms; mutation; cvt ... See more keywords