Frequent Somatic TET2 Mutations in Chronic NK-LGL Leukemia with Distinct Patterns of Cytopenias.
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DOI: 10.1182/blood.2020005831
Abstract: Chronic natural killer large granular lymphocyte (NK-LGL) leukemia, also referred to as chronic lymphoproliferative disorder of NK cells (CLPD-NK), is a rare disorder defined by prolonged expansion of clonal NK cells. Similar prevalence of STAT3… read more here.
Keywords: chronic lgl; tet2 mutations; mutations chronic; lgl leukemia ... See more keywords
Linking the KIR phenotype with STAT3 and TET2 mutations to identify chronic lymphoproliferative disorders of NK cells.
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DOI: 10.1182/blood.2020006721
Abstract: Distinguishing chronic lymphoproliferative disorders of NK cells (CLPD-NK) from reactive NK cell expansions is challenging. We assessed the value of NK receptor phenotyping and targeted high-throughput sequencing in a cohort of 114 consecutive patients with… read more here.
Keywords: stat3 tet2; tet2 mutations; disorders cells; lymphoproliferative disorders ... See more keywords
Age-Associated TET2 Mutations: Common Drivers of Myeloid Dysfunction, Cancer and Cardiovascular Disease
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DOI: 10.3390/ijms21020626
Abstract: Acquired, inactivating mutations in Tet methylcytosine dioxygenase 2 (TET2) are detected in peripheral blood cells of a remarkable 5%–10% of adults greater than 65 years of age. They impart a hematopoietic stem cell advantage and… read more here.
Keywords: tet2 mutations; cancer cardiovascular; age; cardiovascular disease ... See more keywords