USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2
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DOI: 10.1126/sciadv.abc9730
Abstract: USP15 deubiquitinase inactivates TET2 to suppress tumor immunity and is a potential therapeutic target of immunotherapy. TET2 DNA dioxygenase is frequently mutated in human hematopoietic malignancies and functionally inactivated in many solid tumors through a… read more here.
Keywords: tet2 usp15; suppresses tumor; tumor immunity; tet2 ... See more keywords