Epigenetic downregulation of TET3 reduces genome‐wide 5hmC levels and promotes glioblastoma tumorigenesis
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DOI: 10.1002/ijc.32520
Abstract: Loss of 5‐hydroxymethylcytosine (5hmC) has been associated with mutations of the ten–eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild‐type TET genes can also display low 5hmC levels, suggesting that other… read more here.
Keywords: genome wide; 5hmc levels; epigenetic downregulation; glioblastoma tumorigenesis ... See more keywords
A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis
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DOI: 10.1016/j.celrep.2019.12.092
Abstract: SUMMARY Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver fibrosis. Here we report… read more here.
Keywords: positive feedback; liver fibrosis; feedback loop; tgf ... See more keywords
FRI0031 Dna oxidase enzyme tet3 exacerbates synovial inflammation and bone destruction
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.3613
Abstract: Background In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLSs) play an important role in joint destruction. We have shown a disease-specific DNA methylation pattern in RA patient-derived FLSs (RA FLSs). In 2009, active demethylation enzymes, Ten-Eleven… read more here.
Keywords: none declared; stimulation; destruction; inhibited tet3 ... See more keywords
TET3‐mediated DNA oxidation promotes ATR‐dependent DNA damage response
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DOI: 10.15252/embr.201643179
Abstract: An efficient, accurate, and timely DNA damage response (DDR) is crucial for the maintenance of genome integrity. Here, we report that ten‐eleven translocation dioxygenase (TET) 3‐mediated conversion of 5‐methylcytosine (5mC) to 5‐hydroxymethylcytosine (5hmC) in response… read more here.
Keywords: dna damage; tet3; atr dependent; response ... See more keywords
Integrated analysis revealing the role of TET3-mediated MUC13 promoter hypomethylation in hepatocellular carcinogenesis.
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DOI: 10.2217/epi-2022-0395
Abstract: Aim: To explore the function and underlying mechanism of MUC13 in hepatocellular carcinoma (HCC) oncogenesis. Materials & Methods: Online databases and software were used to perform analyses of expression, methylation and enrichment pathway. Experiments were… read more here.
Keywords: promoter; muc13 promoter; promoter hypomethylation; tet3 ... See more keywords