Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons
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DOI: 10.1101/2022.09.26.509559
Abstract: The formation of neural circuits requires extensive interactions of cell-surface proteins to guide axons to their correct target neurons. Trans-cellular interactions of the adhesion G protein-coupled receptor latrophilin-2 (Lphn2) with its partner teneurin-3 instruct the… read more here.
Keywords: lphn2; tethered agonist; protein coupling; context dependent ... See more keywords
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism
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DOI: 10.7554/elife.69061
Abstract: The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR ADGRF5/GPR116 have not been completely deciphered. We set out to investigate the physiological importance of autocatalytic cleavage upstream of the agonistic… read more here.
Keywords: agonist mediated; tethered agonist; adhesion gpcr; gpr116 ... See more keywords