Rhodium-catalyzed diastereoselective synthesis of highly substituted morpholines from nitrogen-tethered allenols.
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DOI: 10.1039/d3cc00151b
Abstract: Rhodium-catalyzed intramolecular cyclization of nitrogen-tethered allenols was investigated for the synthesis of functionalized morpholines. By using this strategy, various N-protected 2,5- and 2,6-disubstituted as well as 2,3,5- and 2,5,6-trisubstituted morpholines were obtained via an atom-economic… read more here.
Keywords: nitrogen tethered; diastereoselective synthesis; tethered allenols; catalyzed diastereoselective ... See more keywords