Intracellular distribution of new tacrine analogues as a potential cause of their cytotoxicity against human neuroblastoma cells SH-SY5Y
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2241-6
Abstract: Four new glyco-conjugated tacrine derivatives, 4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (1), 4-(2,3,4,6-tetra-O-acetyl-β-D-mannopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (2), 2′-(1,2,3,4-tetrahydroacridin-9-yl)hydrazono-3′-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-1′,3′-thiazolidin-4′-one (3) and [2′-(1,2,3,4-tetrahydro-acridin-9-yl)hydrazono-3′-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4′-oxothiazolidin-5-yliden]acetate (4) were synthesized and their characteristics were investigated. All of the novel derivatives were found to inhibit acetylcholinesterase obtained from Electrophorus electricus… read more here.
Keywords: human neuroblastoma; tetra acetyl; cytotoxicity; neuroblastoma cells ... See more keywords
The interaction of 5,10,15,20-tetrakis [4- (2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl) phenyl] porphine with biopolymers
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DOI: 10.1016/j.dyepig.2018.10.034
Abstract: Abstract Glycosized porphyrins are promising compounds for using in PDT, since they combine the ability to act as a photosensitizer, and their saccharide residues provide an increased tumorotropicity of this compound in the affected cells.… read more here.
Keywords: phenyl porphine; galactopyranosyl phenyl; tetrakis tetra; acetyl galactopyranosyl ... See more keywords
Synthesis of Glycosides with 4-(4-Hydroxyphenyl)-1,2,3-thia- and -selenadiazole Aglycones
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DOI: 10.1134/s1070363219070089
Abstract: Glycosylation of 4-(4-hydroxyphenyl)-1,2,3-thia(selena)diazoles with 1-α-bromo-2,3,4,6-tetra-O-acetyl-D-glucopyranose, 1-α-bromo-2,3,4,6-tetra-O-acetyl-D-galactopyranose, and 1-α-bromo-2,3,5-tri-O-acetyl-D-xylopyranose under the conditions of interphase catalysis has afforded the corresponding acetylated glycosides. An alternative pathway of selenadiasole glycosides synthesis from semicarbazones of 1-β-O-(4-acetylphenyl)-2,3,4,6-tetra-O-acetyl-D-glucopyranose, -2,3,4,6-tetra-O-acetyl-D-galactopyranose, and -2,3,5-tri-O-acetyl-D-xylopyranose via… read more here.
Keywords: hydroxyphenyl thia; glycosides hydroxyphenyl; synthesis glycosides; tetra acetyl ... See more keywords