A facile on-bead method for fully symmetric tetra-substituted DOTA derivatizations using peptoid moieties.
Sign Up to like & getrecommendations! Published in 2019 at "Biopolymers"
DOI: 10.1002/bip.23249
Abstract: The metal-chelated 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) has made a significant impact on the field of diagnostic imaging. This imaging mechanism is largely dependent on the four side arm functionalities around the DOTA scaffold. We previously demonstrated… read more here.
Keywords: tetra substituted; symmetric tetra; fully symmetric; substituted dota ... See more keywords
Solid‐Phase Synthesis of 1,3,5,6‐Tetra‐Substituted 3,5‐Dihydroimidazo[4,5‐c][1,2]Thiazin‐4(1H)‐One 2,2‐Dioxide Derivatives
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70045
Abstract: The synthesis of 1,3,5,6‐tetra‐substituted 3,5‐dihydroimidazo[4,5‐c][1,2]thiazin‐4(1H)‐one 2,2‐dioxide derivatives was optimized through solid‐phase synthesis. Synthetic strategies such as Merrifield resin, Thorpe‐Ziegler reaction, Mitsunobu reaction, intramolecular cyclization, and desulfonative nucleophilic substitution were employed to synthesize a total of… read more here.
Keywords: dihydroimidazo thiazin; tetra substituted; synthesis; thiazin one ... See more keywords
Synthesis of Tetra-Substituted Trifluoromethyl-3,1-Benzoxazines by Transition-Metal-Catalyzed Decarboxylative Cyclization of N-Benzoyl Benzoxazinones.
Sign Up to like & getrecommendations! Published in 2021 at "ChemistryOpen"
DOI: 10.1002/open.202100094
Abstract: Invited for this month's cover are the group of Norio Shibata at Nagoya Institute of Technology (Japan). The cover picture is inspired by the diversity in the ocean also in cyberspace. In the present research,… read more here.
Keywords: tetra substituted; transition metal; synthesis tetra; benzoxazines transition ... See more keywords
Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Investigational New Drugs"
DOI: 10.1007/s10637-019-00813-4
Abstract: Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by activating BRAF mutations. Despite the initial success of selective BRAF inhibitors, only few patients exhibited complete responses, whereas many showed disease progression. Melanoma… read more here.
Keywords: tetra substituted; pyrrole derivatives; substituted pyrrole; p53 ... See more keywords
Aggregation-induced emission and reversible mechanofluorochromic characteristics of tetra-substituted tetrahydropyrimidine derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2019.03.004
Abstract: Abstract Organic compounds possessing aggregation-induced emission (AIE) and mechanofluorochromic characteristics are promising in chemo/biosensors and data storage. Here, seven tetra-substituted tetrahydropyrimidine derivatives (TTHPs), products of efficient four-component reactions (4CR), were designed and synthesized for investigation… read more here.
Keywords: emission; mechanofluorochromic characteristics; aggregation induced; tetra substituted ... See more keywords
Synthesis of tetra-substituted phthalocyanines bearing 2-(ethyl(m-tolyl)amino)ethanol: Computational and photophysicochemical studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Photochemistry and Photobiology A: Chemistry"
DOI: 10.1016/j.jphotochem.2018.12.038
Abstract: Abstract This work presents the synthesis of 4-(2-(ethyl(m-tolyl) amino) ethoxy) phthalonitrile (1) as ligand and its peripherally tetrasubstituted metal-free (2) and metallophthalocyanines (3–5) derivatives. Synthesized compounds were characterized by standart spectroscopy methods. The molecular structure… read more here.
Keywords: synthesis tetra; tetra substituted; tolyl amino; ethyl tolyl ... See more keywords
DNA/BSA binding studies of peripherally tetra substituted neutral azophenoxy zinc phthalocyanine
Sign Up to like & getrecommendations! Published in 2020 at "Polyhedron"
DOI: 10.1016/j.poly.2019.114208
Abstract: Abstract A tetra substituted neutral zinc phthalocyanine (ZnPc-4) bearing 4-phenylazophenoxy group at the periphery had been prepared from zinc acetate dihydrate Zn(CH3COO)2·2H2O and 4-(phenylazophenoxy)phthalonitrile. The interaction of neutral metallophthalocyanine, ZnPc-4 with Calf Thymus (CT) DNA… read more here.
Keywords: tetra substituted; dna; substituted neutral; bsa binding ... See more keywords
Investigation of photophysicochemical properties of non-peripherally tetra-substituted metal-free, Mg(II), Zn(II) and In(III)CI phthalocyanines
Sign Up to like & getrecommendations! Published in 2020 at "Polyhedron"
DOI: 10.1016/j.poly.2020.114727
Abstract: Abstract In the present work, the synthesis, characterization, photophysicochemical and aggregation properties of non-peripherally tetra-substituted metal-free (H2Pc), Mg(II) (MgPc), Zn(II) (ZnPc), and In(III)CI (InCIPc) phthalocyanines containing tetra (2,3-dihydro-1,4-benzodioxin-2-ylmethoxy) moieties were reported. The spectroscopic techniques were… read more here.
Keywords: tetra substituted; non peripherally; substituted metal; properties non ... See more keywords
Syntheses of Tetrahydropyran Type 8,7'-Neolignans Using a Ring-Expansion Reaction and Tetrahydrofuran Type 8,7'-Neolignans to Discover a Novel Phytotoxic Neolignan.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c01998
Abstract: One novel tri-substituted tetrahydropyran type 8,7'-neolignan and its enantiomer with higher enantiomeric excess were synthesized from all cis-tetra-substituted tetrahydrofuran with an iodomethyl group by a hydride or H2 ring-expansion reaction. The normal hydride reductions of… read more here.
Keywords: type neolignans; tetra substituted; type; expansion reaction ... See more keywords
Carbon nanofiber/taurine-catalyzed synthesis of coumarin and 1,2,4,5-tetra-substituted imidazole derivatives under metal-free conditions
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-61249-2
Abstract: The main subject of this research is the development of a suitable, efficient, and biocompatible carbon nanofiber-based catalytic system for the synthesis of coumarin and 1,2,4,5-tetra-substituted imidazoles. Brønsted acid carbon nanofiber/taurine catalyst was made during… read more here.
Keywords: tetra substituted; catalyst; synthesis coumarin; nanofiber taurine ... See more keywords
Zn(ii) phthalocyanines tetra substituted by aryl and alkyl azides: design, synthesis and optical detection of H2S
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/d0nj00383b
Abstract: Two novel Zn(II)-phthalocyanines having: (i) aryl azide (3) and (ii) alkyl azide (7) functional groups at the peripheral positions have been designed/synthesized for hydrogen sulfide (H2S) sensing purposes, and their photocharacteristic properties were investigated in… read more here.
Keywords: tetra substituted; detection; aryl alkyl; phthalocyanines tetra ... See more keywords