Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the experimental analysis of behavior"
DOI: 10.1002/jeab.754
Abstract: The dopamine-depleting agent tetrabenazine alters effort-based choice, suppressing food-reinforced behaviors with high response requirements, while increasing selection of low-cost options. In the present experiments, rats were tested on a concurrent fixed ratio 5/chow feeding choice… read more here.
Keywords: choice; depleting agent; dopamine depleting; tetrabenazine ... See more keywords
Deutetrabenazine: A Review in Chorea Associated with Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Drugs"
DOI: 10.1007/s40265-017-0831-0
Abstract: Oral deutetrabenazine (Austedo™), a reversible inhibitor of vesicular monoamine transporter type 2 (VMAT2) that is structurally related to tetrabenazine is approved for the treatment of chorea symptoms associated with Huntington’s disease (HD). In the pivotal… read more here.
Keywords: tetrabenazine; associated huntington; huntington disease; deutetrabenazine ... See more keywords
Reader response: Evaluating depression and suicidality in tetrabenazine users with Huntington disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000006996
Abstract: I read with interest the article by Schultz et al.,1 which addressed a key issue faced by many clinicians treating patients with Huntington disease (HD)—the conundrum of whether or not to start tetrabenazine (TBZ) for… read more here.
Keywords: tetrabenazine; depression suicidality; huntington disease; reader response ... See more keywords
Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics11010044
Abstract: Thorough studies of previous analytical stress data of tetrabenazine, a dopamine depleting agent, showed a potential susceptibility to acidic conditions. Hence, the behavior of tetrabenazine acidic solutions was studied by LC-MS and NMR spectroscopy. Reverse-phase… read more here.
Keywords: tetrabenazine; tetrabenazine acid; behaviour tetrabenazine; acid medium ... See more keywords