Synthesis of the Tetracyclic Structure of Batrachotoxin Enabled by Bridgehead Radical Coupling and Pd/Ni-Promoted Ullmann Reaction.
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DOI: 10.1021/acs.orglett.7b03482
Abstract: The steroidal ABCD-ring system of the potent neurotoxin batrachotoxin was efficiently assembled in a convergent fashion. Bridgehead radical coupling between the simple AB-ring and D-ring fragments (3 and 4) formed the sterically congested linkage at… read more here.
Keywords: bridgehead radical; promoted ullmann; tetracyclic structure; ullmann reaction ... See more keywords