Diastereoselective synthesis of functionalized tetrahydro-γ-carbolines via a [3 + 3] cycloaddition of 2,2′-diester aziridines with β-(indol-2-yl)-α,β-unsaturated ketones
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DOI: 10.1016/j.cclet.2019.09.002
Abstract: Abstract A Sc(OTf)3-catalyzed [3 + 3] cycloaddition of 2,2′-diester aziridines with β-(indol-2-yl)-α,β-unsaturated ketones was developed, affording polysubstituted tetrahydro-γ-carbolines in single diastereoisomers in good to excellent yields. read more here.
Keywords: tetrahydro carbolines; diester aziridines; unsaturated ketones; aziridines indol ... See more keywords
An overview on synthetic entries to tetrahydro-β-carbolines
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DOI: 10.1016/j.tet.2019.01.004
Abstract: Abstract The tetrahydro-β-carboline (THBC) nucleus is a predominant feature of a vast array of naturally occurring alkaloids. Most of these alkaloids have been found to exhibit significant biological activities, which promote to develop a plethora… read more here.
Keywords: overview synthetic; entries tetrahydro; tetrahydro carbolines; synthetic entries ... See more keywords
Organic base-promoted efficient dehydrogenative/decarboxylative aromatization of tetrahydro-β-carbolines into β-carbolines under air
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DOI: 10.1016/j.tetlet.2019.02.020
Abstract: Abstract Organic base DBN has been identified as an efficient reagent for promoting the dehydrogenative/decarboxylative aromatization of tetrahydro-β-carbolines under air atmosphere, to access the corresponding β-carbolines in moderate to good yields. The utility of this… read more here.
Keywords: organic base; tetrahydro carbolines; carbolines air; aromatization tetrahydro ... See more keywords
Synthesis of tetrahydro-1H-indolo[2,3-b]pyrrolo[3,2-c]quinolones via intramolecular oxidative ring rearrangement of tetrahydro-β-carbolines and their biological evaluation
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DOI: 10.1039/c7nj04616b
Abstract: A simple oxidative ring rearrangement of diversely substituted 1-(2-amminoaryl)-tetrahydro-β-carbolines has been developed to generate architecturally interesting tetrahydro-1H-indolo[2,3-b]pyrrolo[3,2-c]quinolones. This unique transformation involves four reaction centers (aniline, C1-carboline and C2/C3 of indole) and utilizes tert-butylhypochlorite as the… read more here.
Keywords: oxidative ring; tetrahydro carbolines; tetrahydro indolo; tetrahydro ... See more keywords
Highly diastereoselective crystallization-induced asymmetric transformation of 1,3-disubstituted-tetrahydro-β-carbolines in water
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DOI: 10.1039/c7ra08811f
Abstract: A green and highly stereoselective method for the synthesis of cis or trans-1,3-disubstituted-tetrahydro-β-carbolines has been developed using water as the solvent. A mixture of cis and trans-1,3-disubstituted-tetrahydro-β-carboline hydrochlorides can be converted to a single cis… read more here.
Keywords: induced asymmetric; disubstituted tetrahydro; tetrahydro carbolines; water ... See more keywords
Electrochemical oxidative rearrangement of tetrahydro-β-carbolines in a zero-gap flow cell
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DOI: 10.1039/d2sc03951f
Abstract: Oxidative rearrangement of tetrahydro-β-carbolines (THβCs) is one of the most efficient methods for the synthesis of biologically active spirooxindoles, including natural products and drug molecules. Here, we report the first electrochemical approach to achieve this… read more here.
Keywords: oxidative rearrangement; flow; tetrahydro carbolines; rearrangement tetrahydro ... See more keywords
Indication of Pd–C or Cu–C Intermediates in Bimetallic Nanoclusters During Pd/Au-PVP- or Cu/Au-PVP-Catalyzed Oxidations of endo -4-Oxatricyclo[5.2.1.0 2,6 ]-8-decene and Tetrahydro-γ-carbolines
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DOI: 10.1055/a-2001-6888
Abstract: Catalytic oxidations of tricyclic endo-norbornene-fused tetrahydrofuran with bimetallic nanoclusters Cu/Au-PVP and H2O2 or t-BuOOH as an oxidant provided C-H bond oxidation adjacent to the ether function and 4-oxa-tricyclo[5.2.1.0]-8,9-exo-epoxydecane (4), however, oxidation with Pd/Au-PVP took place… read more here.
Keywords: bimetallic nanoclusters; nanoclusters pvp; tetrahydro carbolines; bond forming ... See more keywords