Identification, Structure–Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators
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DOI: 10.1021/acs.jmedchem.0c01050
Abstract: Cystic fibrosis (CF) is a life-threatening autosomal recessive disease, caused by mutations in the CF transmembrane conductance regulator (CFTR) chloride channel. CFTR modulators have been reported to address the basic defects associated with CF-causing mutations,… read more here.
Keywords: cftr; cftr potentiators; tetrahydro pyrido; activity relationship ... See more keywords