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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.08.018
Abstract: A series of novel N-substituted 3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxy- lic acid derivatives were synthesized and evaluated for their biological activities. Among all synthesized target compounds, 13d exhibited the most potent antiproliferative activity against HeLa, SMMC-7721, K562 cell line (IC50 = 0.126 μM,…
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Keywords:
tetrahydro quinoxaline;
tubulin polymerization;
acid derivatives;
oxo tetrahydro ... See more keywords