Affinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two
Sign Up to like & getrecommendations! Published in 2017 at "Cannabis and Cannabinoid Research"
DOI: 10.1089/can.2016.0032
Abstract: Abstract Introduction: Cannabis biosynthesizes Δ9-tetrahydrocannabinolic acid (THCA-A), which decarboxylates into Δ9-tetrahydrocannabinol (THC). There is growing interest in the therapeutic use of THCA-A, but its clinical application may be hampered by instability. THCA-A lacks cannabimimetic effects;… read more here.
Keywords: affinity efficacy; thca; affinity; cannabinoid receptor ... See more keywords
Delta-9-Tetrahydrocannabinolic Acid B: A Mechanism for its Formation in Cannabis.
Sign Up to like & getrecommendations! Published in 2022 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2021.0216
Abstract: There appears to be consensus among Cannabis biologists that delta-9-tetrahydrocannabinolic acid A (THCA-A) is the exclusive product of the enzyme THCA synthase. This then leaves an open question for formation of the THCA-A structural isomer,… read more here.
Keywords: cannabis; acid; delta tetrahydrocannabinolic; thca ... See more keywords
Evaluation of tetrahydrocannabinolic acid (THCA) synthase polymorphisms for distinguishing between marijuana and hemp
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.15045
Abstract: The Controlled Substances Act (CSA) classifies marijuana (Cannabis sativa) as a Schedule I illicit drug. However, the recent Agriculture Improvement Act of 2018 (U.S. Farm Bill) removed hemp from the definition of marijuana in the… read more here.
Keywords: crop; hemp; thca synthase; thca ... See more keywords
Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14019
Abstract: Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ9‐tetrahydrocannabinol have been extensively investigated, the bioactivity of… read more here.
Keywords: acid potent; agonist neuroprotective; potent ppar; ppar agonist ... See more keywords
Cis-Δ9-tetrahydrocannabinolic acid occurrence in Cannabis sativa L.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.2139/ssrn.4120999
Abstract: Cannabidiolic acid (CBDA) and trans-Δ9-tetrahydrocannabinolic acid (trans-Δ9-THCA) are known to be the major phytocannabinoids in Cannabis sativa L., along with their decarboxylated derivatives cannabidiol (CBD) and trans-Δ9-tetrahydrocannabinol (trans-Δ9-THC). The cis isomer of Δ9-THC has been… read more here.
Keywords: cannabis sativa; tetrahydrocannabinolic acid; rich varieties; thc ... See more keywords