Intramolecular Copper-Catalyzed Asymmetric Propargylic [4 + 2]- Cycloaddition toward Optically Active Tetrahydroisoindolo[2,1-a]quinoxalines.
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DOI: 10.1021/acs.orglett.2c02155
Abstract: An intramolecular Cu-catalyzed asymmetric propargylic [4 + 2] cycloaddition of bis-N-nucleophile-functionalized propargylic esters has been realized in the support of a chiral tridentate N-ligand, (S,S)-Pybox-diOAc, leading to chiral tetrahydroisoindolo[2,1-a]quinoxalines in high yields and with good… read more here.
Keywords: propargylic cycloaddition; asymmetric propargylic; optically active; catalyzed asymmetric ... See more keywords