Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
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DOI: 10.1021/acs.jmedchem.1c01564
Abstract: Our first-generation CXCR4 antagonist TIQ15 was rationally modified to improve drug-like properties. Introducing a nitrogen atom into the aromatic portion of the tetrahydroisoquinoline ring led to several heterocyclic variants including the 5,6,7,8-tetrahydro-1,6-naphthyridine series, greatly reducing… read more here.
Keywords: drug like; cyp 2d6; tetrahydronaphthyridine; cxcr4 ... See more keywords