Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity
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DOI: 10.3389/fchem.2018.00206
Abstract: Tetrahydropyrazino-annelated theophylline (1,3-dimethylxanthine) derivatives have previously been shown to display increased water-solubility as compared to the parent xanthines due to their basic character. In the present study, we modified this promising scaffold by replacing the… read more here.
Keywords: target drugs; tetrahydropyrazino; tetrahydropyrazino annelated; a2a ... See more keywords